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Emerging microbiome-directed therapies in inflammatory bowel disease: beyond diet modification and FMTNARA Subscribed
Inflammatory bowel disease (IBD) is a multifactorial and heterogeneous disorder that remains challenging to manage. Growing evidence implicates the gut microbiome as a key player in IBD pathogenesis, with many patients displaying intestinal dysbiosis that can drive aberrant immune responses. Traditional microbiome-targeted interventions, such as dietary modifications, probiotics, and fecal microbiota transplantation (FMT), hav...
Zusammenfassung Das Klimaschutzpotenzial einer verstärkten thermischen Nutzung des oberflächennahen Untergrundes als saisonaler Speicher bleibt bisher weitestgehend ungenutzt. Als Hindernis wird häufig die Besorgnis vor negativen Veränderungen der Grundwasserchemie angeführt, welche für den Hochtemperatur-Bereich (HT-Bereich) (≤ 90 °C) jedoch größtenteils auf relativ einfachen Laboruntersuchungen beruht. Mit der Zusammenstellu...
Mechanistic modeling of the bioconcentration of (super)hydrophobic compounds in Hyalella aztecaNARA Subscribed
Bioconcentration tests using the freshwater amphipod Hyalella azteca as an alternative to conventional fish tests have recently received much attention. An appropriate computational model of H. azteca could help in understanding the mechanisms behind bioconcentration, in comparison to the fish as test organism. We here present the first mechanistic model for H. azteca that considers the single diffusive processes in the gills...
Calibration of condensation particle counters (CPC) to measure non-volatile particle number (PN) from vehicle emissions is a significant source of uncertainty of the regulated particle number measurements. In this work, the calibration uncertainty of automotive and calibration laboratories was determined in a first-of-its-kind comparison. For this purpose, the counting efficiency of a reference CPC for automotive exhaust emiss...
Summary C4‐dicarboxylates, such as fumarate, l ‐malate and l ‐aspartate represent substrates for anaerobic growth of Escherichia coli by fumarate respiration. Here, we determined whether C4‐dicarboxylate metabolism, as well as fumarate respiration, contribute to colonization of the mammalian intestinal tract. Metabolite profiling revealed that the murine small intestine contained high and low levels of l ‐aspartate and l ‐mala...
Parasite‐mediated selection varying across time and space in metapopulations is expected to result in host local adaptation and the maintenance of genetic diversity in disease‐related traits. However, nonadaptive processes like migration and extinction‐(re)colonization dynamics might interfere with adaptive evolution. Understanding how adaptive and nonadaptive processes interact to shape genetic variability in life‐history and...
Summary The sensor kinase DcuS of Escherichia coli co‐operates under aerobic conditions with the C 4 ‐dicarboxylate transporter DctA to form the DctA/DcuS sensor complex. Under anaerobic conditions C 4 ‐dicarboxylate transport in fumarate respiration is catalyzed by C 4 ‐dicarboxylate/fumarate antiporter DcuB. (i) DcuB interacted with DcuS as demonstrated by a bacterial two‐hybrid system (BACTH) and by co‐chromatography of the...
Mortality rates of wild boar Sus scrofa L. in central EuropeNARA Subscribed
Relationship between survival and yield related traits in Solanum pimpinellifolium under salt stressNARA Subscribed
A subset of the Solanum pimpinellifolium collection maintained by AVRDC—The World Vegetable Center, Taiwan was evaluated to assess effects of salt stress on physiological traits and yield-related traits with the aim of identifying potential S. pimpinellifolium accessions useful for salt tolerance breeding in tomato. We undertook a comparative analysis of yield and plant survival traits under normal and salt stress conditions t...