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Periodical cicada ( Magicicada spp.) ranges have continued to decline even as their habitat has rebounded from historic lows. This counterintuitive trajectory may be a consequence of Magicicada 's limited dispersal capabilities combined with their requirement that individual host trees survive across decades. Indeed, we find that the presence of Magicicada breeding populations is best predicted by tree cover in 1930, not by pr...
Supine-dependent OSA is a well-recognised OSA phenotype and may relate to craniofacial structure. Our aim was to assess whether craniofacial photos are able to identify positional OSA, specifically supine-isolated OSA, in comparison to non-positional OSA. Frontal and profile craniofacial photographs of participants were acquired according to a standardised protocol. Photographs were analysed and compared between non-positional...
Revisiting the Anti-Drug Antibody Assay Drug Tolerance of a Commercial Biological ProductNARA Subscribed
Drug tolerance (DT) is a critical attribute of anti-drug antibody (ADA) assays for assessing clinical immunogenicity. We present a unique situation where a previously approved commercial product, atezolizumab, required re-assessment of the assay DT to meet an increased drug exposure demand arising from a new route of administration (subcutaneous) and align with updated health authority (HA) regulations. Rather than redevelop t...
Aim Ibla cumingi , a rocky intertidal barnacle, belongs to the order Iblomorpha, which is known as a living fossil with plesiomorphic characters and of Palaeozoic origin. This species lives cryptically inside crevices across the Indo‐Pacific. We aim to investigate the phylogeography of this ancient barnacle, to test whether it forms a single phylogenetic unit or consists of different clades of long palaeo‐historical or recent...
Morphological and Chemical Changes in the Trophozoites and Cysts of Acanthamoeba Castellanii Induced by Camellia Sinensis ExtractsNARA Subscribed
Purpose Acanthamoeba castellanii is an important opportunistic human protozoal pathogen that can cause both skin, ocular and brain infections. Recent studies have established that brews and solvent extract (SE) of green tea ( Camellia sinensis ) can inhibit the growth and encystation of A. castellanii . Here we characterized those growth and encystation inhibitions. Methods Herein, we characterize of the morphological and chem...
Deep operator and SSA collaboration for space sustainabilityNARA Subscribed