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Earth's biodiversity is central to ecosystem health and resilience, providing essential functions and services. The Red Sea is a recognised marine biodiversity hotspot with high endemism and unique environmental conditions that support extensive but poorly resolved biodiversity. Here, we applied metagenomic analyses to sediment samples collected from coastal to deep‐sea environments during the Red Sea Decade Expedition 2022 to...
The in vitro alkaline comet assay with liver models as a complementary tool for genotoxicity assessment of N-nitrosaminesNARA Subscribed
N -nitrosamine (NA) impurities in pharmaceuticals represent “cohort of concern” compounds under ICH M7(R2), due to their mutagenic/carcinogenic potential, involving cytochrome P450 (CYP)-mediated metabolic activation. Increasing interest in mammalian cell-based genotoxicity/mutagenicity assays prompted our assessment of the in vitro alkaline comet assay regarding its predictive power for NAs. Here, precision-cut liver slices (...
This narrative review recommends an innovative, farmer-friendly controlled-pollination approach for smallholder farmers to produce their own coconut ( Cocos nucifera ) seednuts on farm. Over millennia, these smallholder farmers have created a wide range of coconut diversity and associated traditional knowledge. However, for seednuts produced under natural, open pollination, the male parent identity is not known. Often, less th...
Modeling of gene regulatory networks: an annotated glossaryNARA Subscribed
Learn to listen and listen to learn: reflections from a co-production process between researchers and composersNARA Subscribed
As platforms for dialogue, art-science collaborations hold the potential to cross disciplinary boundaries to better understand and engage the public in addressing sustainability challenges. Moving beyond documenting outcomes, this study details how researchers and composers combined science communication and artistic expression to co-produce performances as part of the Baltic Sea Festival Science Lab. Drawing on insights from...
Diversity and functional group composition drive biogeographic patterns in marine biogenic structural complexityNARA Subscribed
Biogenic structural complexity is a key driver of biodiversity and ecosystem functioning, yet its ecological and environmental determinants remain poorly understood across broad biogeographic scales. Here, we conducted standardized 90‐day field experiments at 16 coastal sites, spanning a 41‐degree latitudinal gradient, using naturally assembled marine fouling communities on settlement panels. We measured rugosity as our metric...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
SNAPSHOT USA 2024: Year 6 of the Coordinated National Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multi‐contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of speci...