The ~75 ka Young Toba super‐eruption was a catastrophic extreme event that spewed vast quantities of volcanic ash and aerosols and is argued to have caused a drastic volcanic winter, climatic upheaval, and a human genetic bottleneck. The global and regional impacts of the eruption on climate dynamics and past hominin populations are strongly contested due to conflicting global climatic records and archeological datasets. The I...

Breast cancer is a common form of cancer that affects both men and women. One of the most common types of genomic flaws in cancer is the aberrations in the PI3K/AKT/mTOR pathway. The benefit of dual targeting PI3K as well as mTOR is that the kinase-positive feedback loops are more effectively inhibited. Therefore, in the current study, structure-based models like molecular docking, MM-GBSA, Qikprop, induced fit docking, simula...