B.A. Edwards results 294
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Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in BrazilNARA Subscribed
Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort usi...
Adaptive area-wide management for suppressing spruce budworm outbreaks: effectiveness of the early intervention strategyNARA Subscribed
In eastern North America, two main insecticide-based strategies are used to manage spruce budworm ( Choristoneura fumiferana ) outbreaks. The traditional ‘Foliage Protection Strategy’ (FPS) focuses on temporarily reducing defoliation and tree mortality in high-value stands, allowing outbreaks to progress naturally in surrounding areas. The ‘Early Intervention Strategy’ (EIS) is an adaptive, area-wide management approach that t...
Calibration of the species threat abatement and restoration metric's threat abatement component in a Costa Rican landscapeNARA Subscribed
Achieving global conservation policy goals requires the ability to set and measure progress toward science‐based targets for biodiversity. The species threat abatement and restoration (STAR) metric was developed to enable actors to set science‐based targets for species. STAR scores quantify the potential contribution of actions to abate threats and restore habitat to reduce species extinction risk in a particular place and can...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Linking crystal shape and dynamic undercooling: a new framework for inferring magmatic crystallization historiesNARA Subscribed
Magmas contain crystals exhibiting diverse shapes and sizes, yet the relationship between crystal shape (specifically aspect ratio) and undercooling ( $$\Delta T$$ ), the driving force for crystallization, remains poorly constrained. Crystal shape should correlate with undercooling because undercooling governs the growth regime (interface-controlled versus diffusion-controlled) and thus the resulting crystal form. Prior experi...
Congener Conflict: Invasive Barred Owl Landscape Use Across the Range of the Northern Spotted OwlNARA Subscribed
Aim To map the probability of landscape use of invading barred owls ( Strix varia ) across the range of the threatened northern spotted owl ( S. Occidentallis Caurina ) in the Pacific Northwest, USA , identifying environmental drivers of barred owl landscape use to inform targeted management interventions. Location Forests of the Pacific Northwest, USA. Taxon Barred Owl ( Strix varia ). Methods We deployed 4081 autonomous reco...
A Scoping Review of Mosquito Vector Range Shifts: Widespread Expansions and Evidence Gaps in Climate AttributionNARA Subscribed
As global temperatures rise, concerns about shifting mosquito ranges—and accompanying changes in the transmission of malaria, dengue, and other diseases—are mounting. However, systematic evidence for climate‐driven changes in mosquito ranges remains limited. We conducted a scoping review following PRISMA ‐ ScR guidelines of studies documenting expansions or contractions in medically important mosquito species. In total, 178 st...
Purpose Law enforcement cadets (LECs) undergo subject control technique training that may expose them to repetitive head impacts recorded as head acceleration events (HAEs) using instrumented mouthguards. Prior research suggests that sex and/or gender differences in HAE frequency and magnitude vary by sport. This study aimed to examine sex differences in HAE exposure among LECs during training. Methods We collected HAEs from 8...