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NARA Subscribed2
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Springer Nature2
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AAPS PharmSciTech1
Pharmaceutical Research1
Publication Year
20252
Benjamin Myatt results 2 · Newest (Page 1/1, per page 25)
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The Role of Low Global Warming Potential Propellants on Suspension Metered Dose Inhaler SpraysNARA Subscribed
AAPS PharmSciTech · 2025 · Vol. 26 · Issue 5 · Springer
Daniel J. Duke; Lingzhe Rao; Benjamin Myatt; Phil Cocks; Stephen Stein; Hui Xin Ong; Paul Young
The reformulation of suspension-based pressurized metered dose inhalers (pMDI) with low global warming potential (GWP) propellants is challenged by wide-ranging changes to their chemicophysical properties such as vapor pressure, density and latent heat. The effect of low-GWP propellants on spray pattern and plume geometry for suspension pMDIs are not fully understood. There is a lack of data regarding the role of propellant ch...
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In-vitro Evaluation of Solution Pressurised Metered Dose Inhaler Sprays with Low-GWP PropellantsNARA Subscribed
Pharmaceutical Research · 2025 · Vol. 42 · Issue 2 · Springer
Daniel J. Duke; Lingzhe Rao; Benjamin Myatt; Phil Cocks; Stephen Stein; Nirmal Marasini; Hui Xin Ong; Paul Young
Purpose The transition from high Global Warming Potential (GWP) propellants such as HFA134a to low-GWP alternatives such as HFA152a and HFO1234ze(E) in pressurised metered dose inhalers (pMDIs) poses a number of challenges for inhaled pharmaceutical product development. Changes in chemicophysical properties will alter product performance, impacting in-vitro bioequivalence metrics. This study investigates those differences usin...
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