Recycling antibodies can enhance therapeutic efficacy by enabling efficient antigen removal through pH-dependent binding mechanisms enabling antibody recycling, but the optimal targets for this strategy remain unclear. This work employs a mathematical modeling approach using a minimal PBPK model, along with global and local sensitivity analyses, to explore how target turnover rates influence the suitability of recycling antibo...

The southern Cape is a key focus for southern African palaeoenvironmental research as it represents the transitional region between temperate westerlies and sub‐tropical rainfall sources. This study presents pollen, plant biomarker, geochemical and charcoal data preserved in the Rietvlei wetland. The bulk of the record spans the last 16 ka, but it also provides rare insights into late Marine Oxygen Isotope Stage (MIS) 3 (ca. 3...