Bruna Machado results 93
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Loss of quality of corneas stored in hypothermic preservation media during processing and evaluation in an eye bank: a cohort studyNARA Subscribed
This study aimed to analyze factors associated with the loss of quality of corneas stored in hypothermic preservation media during processing and evaluation in an eye bank. A cohort study was conducted using records from 422 donors (844 corneas) between January 1, 2022, and March 31, 2024. Corneal quality was determined through slit-lamp biomicroscopy based on 13 morphological criteria, with tissues classified on a Likert-type...
Random mutagenesis combined with genome-scale analysis represents a powerful approach to uncover metabolic reprogramming in non-model microalgae. In this study we investigated the strain Desmodesmus sp. Petrobras/FURG, a thermotolerant and contamination-resistant microalga with potential for large-scale cultivation. UV mutagenesis followed by iodine-vapor screening yielded the starch-deficient mutant tN-30, which maintained wi...
Dual inhibition of MMP-2 and actin dynamics by a novel bis-chalcone: an anticancer strategy for oral squamous cell carcinomaNARA Subscribed
Oral squamous cell carcinoma (OSCC), accounts for approximately 90% of oral cancer cases, and due to its aggressive nature and limited treatment options remains a significant clinical challenge. In the pursuit of novel therapeutic agents, bis-chalcones (a subclass of chalcones) have emerged as promising candidates with multipronged anticancer potential. In this study, we synthesized and evaluated a novel bis-chalcone (B2OCH 3...
Niche Differentiation Among Large Pelagic Fishes in the Southwest Atlantic Revealed by Stable Isotope AnalysisNARA Subscribed
Understanding the trophic ecology of large pelagic fishes is essential to assess their ecological role in marine ecosystems and to develop effective conservation strategies. In the present study, we aimed to provide new information on the trophic ecology of eight large pelagic fish species ( Thunnus atlanticus (blackfin tuna), Thunnus albacares (yellowfin tuna), Katsuwonus pelamis (skipjack tuna), Sarda sarda (Atlantic bonito)...
The emergence of new viral strains has been frequently associated with the onset of outbreaks in different epidemiological settings. This study investigated an acute gastroenteritis (AGE) outbreak, which occurred at a university campus in southern Brazil, in 2024, affecting approximately 30–40% of undergraduate students, with over 400 reported cases. The objectives were to describe the epidemiological and molecular features of...
Successional agroforestry systems as land use that promote the restoration and conservation of ant assemblages in the AmazonNARA Subscribed
Land-use changes, driven by the expansion of agriculture and livestock farming, are one of the main drivers of biodiversity loss in the Amazon region. In this context, Succesional Agroforestry Systems - SAFs, emerge as a potential alternative to reconcile agricultural production with biodiversity conservation and restoration. This study assessed the impact of different land-use types on ant diversity and the composition of hab...