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Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Interplay between saltmarsh carbon burial and lateral exchange in coastal wetlands: The role of biomorphodynamic feedbackNARA Subscribed
Understanding the carbon sequestration of saltmarshes and the role of biomorphodynamic feedback are essential for the protection, management, and adaptation to climate change of coastal blue carbon ecosystems. We developed a biomorphodynamic model that simultaneously considers carbon vertical burial and lateral exchange of soil organic carbon and validated this model against field measurements. This model was then used to exam...
Identification of Regulatory Elements in Primary Sensory Neurons Involved in Trauma-Induced Neuropathic PainNARA Subscribed
Chronic pain is a significant public health issue that is often refractory to existing therapies. Here we use a multiomic approach to identify cis-regulatory elements that show differential chromatin accessibility and reveal transcription factor (TF) binding motifs with functional regulation in the rat dorsal root ganglion (DRG), which contain cell bodies of primary sensory neurons, after nerve injury. We integrated RNA-seq to...
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