Down syndrome (DS), or trisomy 21 (T21), represents the most common genetic cause of intellectual disability worldwide and is associated with a wide range of medical, developmental, and neurodegenerative conditions, including a universal predisposition to early-onset Alzheimer’s disease (AD). Since its establishment in 2014, the Trisomy 21 Research Society (T21RS) has provided a global forum for advancing DS research across di...

This study aimed to assess whether dietary nitrate supplementation with resistance training (RT) augments gait performance and functional mobility in inactive middle-aged and older adults. We hypothesized that combining nitrate-rich beetroot juice (BRJ) with RT would yield improvements in gait and functional mobility compared to RT with nitrate-depleted beetroot juice placebo (PLA) supplementation. In this 12-week, randomized,...

There is overwhelming evidence that tropical coral reefs are severely impacted by human induced climate change. Assessing the capability of reef-building corals to expand their tolerance limits to survive projected climate trajectories is critical for their protection and management. Acclimation mechanisms such as developmental plasticity may provide one means by which corals could cope with projected ocean warming and acidifi...