C. Der results 1,094
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Mild cognitive impairment and pre-frailty show distinct plasma multi-omic signatures: a cross-sectional studyNARA Subscribed
Frailty and cognitive impairments frequently co-occur in older adults. It remains unclear whether this overlap reflects shared underlying biological mechanisms or parallel but distinct disease pathways. We hypothesize that physical weakness and cognitive impairment share circulating markers already in an early disease stage. We therefore recruited and analyzed a relatively healthy population with partially overlapping pre-frai...
A speed-oriented phenotype is beneficial for 1500 m rowing at the Los Angeles 2028 Olympic GamesNARA Subscribed
Purpose The shorter rowing course at the Los Angeles 2028 Olympics, which is 1500 m instead of 2000 m, potentially alters the physiological demands of racing. This study aims to elucidate whether the shortened distance favours rowers with a more speed-oriented phenotype, using two non-invasive profiling approaches: locomotor profiling and force-velocity (F-v) profiling. Methods Nine nationally competitive male rowers completed...
Freshwater mollusk shells serve as valuable archives for the reconstruction of past environmental conditions as they record water temperatures in their stable isotopic compositions during biomineralization. Yet, the impact of food availability on these isotopic records has never been fully explored. This study addresses that gap by investigating the effects of both temperature and food regime on the stable carbon (δ 13 C) and...
An efficient floral dipping transformation method for the metal hyperaccumulator Noccaea caerulescensNARA Subscribed
Noccaea caerulescens is a metal hyperaccumulator plant species with the capacity to accumulate high concentrations of zinc (Zn), cadmium (Cd) and nickel (Ni). Several candidate genes have so far been associated with accumulation and tolerance of these metals, but gene function analysis has been cumbersome in the absence of an efficient stable plant transformation method for N. caerulescens . A previously identified mutation in...
Erosion and habitat loss on intertidal flats are increasingly fought through large-scale sediment nourishment. Yet the impact of nourishment on short-term bed-level dynamics remains poorly quantified. Daily erosion–accretion events shape the immediate physical environment experienced by benthic infauna: repeated burial and re-exposure set the physical bounds of the ecological niche, making bed-level dynamics a key indicator of...
Comparative life cycle assessment and implementation of disposable, biodegradable, and reusable absorbent mats in healthcareNARA Subscribed
Purpose Absorbent mats are widely used in healthcare, with around 23 million consumed annually in the Netherlands. These single-use products are typically discarded after use, making them non-circular. As healthcare transitions towards more sustainable practices, understanding the environmental impact of these mats and evaluating reusable alternatives is essential. This study aimed to compare the life cycle environmental impac...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Butternut ( Juglans cinerea L.) is a rapidly declining tree species threatened by Ophiognomonia clavigignenti-juglandacearum (Oc-j), the causal agent of butternut canker. The introduction of Japanese walnut ( Juglans ailantifolia Carrière), which hybridizes with butternut and exhibits greater resistance to the disease, presents both a conservation challenge and a potential avenue for genetic improvement. Identifying non-admixe...
Transition to fetal calf serum-free culture enhances kidney proximal tubule cell bioenergetics and allows pharmacological applicationsNARA Subscribed
Proximal tubule in vitro systems are important tools in pre-clinical drug development, providing insights into drug disposition and safety. Cells are often cultured in medium containing fetal calf serum (FCS); however, FCS addition is not physiologically relevant for cells of human origin. Here, in vitro cultures of human kidney proximal tubule cells were transitioned to FCS-free medium. The impact of FCS-free medium on matura...