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The decisions and conditions of animals often carry over to influence fitness in subsequent seasons or years. The condition, choices, and behaviors of parents may have a huge influence on offspring survival, not only when they are nutritionally dependent (i.e., pre-weaning or pre-fledgling), but also after they have reached independence but before adulthood (i.e., post-weaning or post-fledgling). Using a long-lived, iteroparou...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Rationale Cannabis use disorder (CUD) affects over 50 million people globally. Emerging evidence shows that some people with CUD may experience altered social cognition (e.g., emotion recognition or differentiation). These impairments can affect their ability to understand others’ emotional states and navigate social interactions, potentially contributing to chronic cannabis use, even when it leads to interpersonal problems. H...
Key message Sparse testcrossing with 3-5 testers enhances genetic gain in hybrid breeding programs , offering a practical balance of simple testcross designs , resource efficiency , and increased prediction accuracy for general combining ability. Abstract Sparse testcrossing is an effective strategy for increasing both short- and long-term genetic gain in hybrid breeding programs. Maize hybrid breeding programs aim to develop...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Background Cachexia accounts for about 20% of all cancer-related deaths and it is indicative of poor prognosis and progressive functional impairment. The role of the gut microbiome in the development of cachexia in colorectal cancer (CRC) patients has not been established. Methods Pre-surgical stool samples from n = 103 stage I–III CRC patients in the ColoCare Study were analyzed using 16S rRNA gene sequencing (Illumina) to ch...