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HTLV-1 infection causes chronic immune activation and a prolonged asymptomatic phase, but the functional features that define early disease remain unclear. We evaluated whether spontaneous proliferation (SP) and related functional immune parameters can distinguish clinical stages across the HTLV-1 spectrum. Spontaneous and mitogen-induced lymphoproliferation (PHA, anti-CD3), measured by CFSE dilution, and in vitro cell death,...
Assessment of Human Health Risks in Compressed Earth Blocks with Coal Gangue Replacement: Focus on TCLP and Potentially Toxic ElementsNARA Subscribed
The purpose of this study was to assess the potential human health risks associated with the valorization of coal gangue through the production of Compressed Earth Blocks (CEB). The research included the characterization of the raw materials. Subsequently, mix designs were developed by replacing sand with coal dust, by weight, at replacement levels of 0%, 50%, and 100%. CEB were produced for each coal gangue combination, and t...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Prolonged drought in Tenerife (1990–2022): altitudinal precipitation trends and challenges for water management in island territoriesNARA Subscribed
This study carries out an analysis of a precipitation diminution in Tenerife, located in the Canary Islands. The research focuses on the apparent reduction in precipitation occurring during the 2020s compared to historical climate patterns, a trend that may be accelerated by the impact of climate change. Mean precipitation during the period 1990–2022 undergoes significant reductions, with December experiencing the most pronoun...
Population Genomic Analyses Reveal Geographic Structure in Rhizoctonia solani AG1 ‐ IA Isolates Associated With Agronomic CropsNARA Subscribed
Soilborne fungal pathogens threaten food security, but limited knowledge of their population biology, including genetic variability and population structure, hinders the development of effective strategies to prevent crop losses. Rhizoctonia solani AG‐1 is a significant soilborne pathogen worldwide, divided into subgroups based on host range and molecular diversity. Rhizoctonia solani AG1‐IA causes sheath blight in rice and ae...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Island water stress: analyzing the Canary Islands’ hydrological response to climate changeNARA Subscribed
Climate change and human activities threaten water resources in the Canary Islands, where increasing temperatures and decreasing precipitation intensify water stress. In order to develop strategies to protect water resources, it is necessary to know how water availability will evolve in this region. The Fundación para la Investigación del Clima (FICLIMA) methodology offers high-resolution projections (100 m × 100 m), which all...
A combined structural, petrological, and anisotropy of magnetic susceptibility (AMS) study of the Cisuralian (285 ± 2 Ma) Cerro Redondo dacitic intrusion (Iberian Chain, NE Spain) has been conducted to reconstruct its emplacement kinematics and determine its 3D geometry at the outcrop scale. This small igneous body, covering only 0.17 km 2 , displays a well-defined magmatic foliation that is affected by asymmetrical, steeply p...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The biomedical engineer’s pledge: overview and contextNARA Subscribed
Although biomedical engineering (BME) is a profession with ethical responsibilities comparable to those in medicine, it has, until now, lacked a counterpart to the Hippocratic Oath. While professional societies have established codes of ethics for biomedical engineers, these documents lack the symbolic and ceremonial significance of an oath or pledge. By contrast, the recitation of the Hippocratic Oath, or its modern version,...
This study introduces the first high-resolution hazard probability maps of extreme precipitation for Spain, marking a significant step toward a national climate service for hydrometeorological extremes. Using long-term daily precipitation records from a dense network of stations and incorporating topographic data, the methodology combines the Generalized Pareto distribution with universal kriging to spatially interpolate distr...
Purpose Babesia species are tick-borne protozoan parasites which affect several animal species. Babesia spp. infections are significantly important for veterinary medicine, affecting a wide range of domestic animal species such as dogs, cattle, and horses. In Colombia, studies of Babesia spp. infections in domestic animals are scarce. Thus, the aim of the present study was to explore the circulation of these parasites among do...
The rapid expansion of offshore wind energy requires exploring alternative turbine architectures capable of operating efficiently in deep waters. While horizontal-axis wind turbines (HAWTs) dominate the current market, vertical-axis wind turbines (VAWTs) offer potential advantages in wake recovery, structural integration, and scalability on floating platforms. This work proposes a methodological framework to enable a fair and...