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A practical guide to investigating biomolecular condensates: a comment from the plant communityNARA Subscribed
Biomolecular condensates formed through phase separation have emerged as a central principle of cellular organization, enabling the dynamic regulation of gene expression, signaling, metabolism, and stress responses. While early conceptual advances in condensate biology have largely originated from animal and in vitro systems, plant cells present a unique set of biological and technical challenges, including rigid cell walls, t...
Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330NARA Subscribed
The proteostatic decline in Alzheimer’s disease is well established, and improvement in proteostasis could potentially delay cognitive impairment. One emerging entry point to modulate proteostasis is the regulation of nucleo-cytoplasmic partitioning of proteins across the nuclear pore via karyopherins. The nuclear exportin XPO1 is a key regulator of proteostasis by driving the assembly of ribosomes and by modulating the proces...
The Interplay of Traits, Phylogeny and Abundance Shapes Spatial Mammal Diversity PatternsNARA Subscribed
Aim Terrestrial mammal communities are crucial indicators of tropical ecosystem health and sustainability. However, the role of shared species responses driven by functional traits and phylogenetic relatedness in shaping community assembly remains underexplored for identifying conservation hotspots. Spatial predictions of species diversity also remain limited by approaches that fail to jointly account for species occupancy and...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...