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Humans have facilitated the spread and evolution of invasive species, a pattern that has accelerated with the globalisation of trade and societal development. Consequently, the invasiveness of a species may be determined not only by how many propagules and which genotypes are introduced, but also by its evolutionary history and how humans have interacted with it. Here, we document the population structure and movement of Sahar...
Variants which disrupt splicing are a frequent cause of rare disease that have been under-ascertained clinically. Accurate and efficient methods to predict a variant’s impact on splicing are needed to interpret the growing number of variants of unknown significance (VUS) identified by exome and genome sequencing. Here, we present the results of the CAGI6 Splicing VUS challenge, which invited predictions of the splicing impact...
Conservation resource allocation, small population resiliency, and the fallacy of conservation triageNARA Subscribed
Some conservation prioritization methods are based on the assumption that conservation needs overwhelm current resources and not all species can be conserved; therefore, a conservation triage scheme (i.e., when the system is overwhelmed, species should be divided into three groups based on likelihood of survival, and efforts should be focused on those species in the group with the best survival prospects and reduced or denied...
Electronic monitoring in fisheries: Lessons from global experiences and future opportunitiesNARA Subscribed
Since the beginning of the 21st century, electronic monitoring (EM) has emerged as a cost‐efficient supplement to existing catch monitoring programmes in fisheries. An EM system consists of various activity sensors and cameras positioned on vessels to remotely record fishing activity and catches. The first objective of this review was to describe the state of play of EM in fisheries worldwide and to present the insights gained...
A partner‐switching system controls activation of mixed‐linkage β‐glucan synthesis by c‐di‐GMP in Sinorhizobium melilotiNARA Subscribed
Summary Sinorhizobium meliloti synthesizes a linear mixed‐linkage (1 → 3)(1 → 4)‐β‐ d ‐glucan (ML β‐glucan, MLG) in response to high levels of cyclic diguanylate (c‐di‐GMP). Two proteins BgsA and BgsB are required for MLG synthesis, BgsA being the glucan synthase which is activated upon c‐di‐GMP binding to its C‐terminal domain. Here we report that the product of bgrR (SMb20447) is a diguanylate cyclase (DGC) that provides c‐d...