Bokermannohyla frogs comprise species distributed across different Brazilian biomes, several of which are currently listed as endangered species. These anurans host a diversity of parasites that may negatively affect their survival. Several tick species of the family Argasidae and chigger mites of the family Leeuwenhoekiidae exhibit host specificity toward this group. Here, we report a case of co-parasitism by argasid ticks an...

A novel bacterial species was isolated from the nasal mucosa of Hereford cattle exhibiting early clinical signs of infectious bovine keratoconjunctivitis on a beef cattle farm in the Pampa biome, southern Brazil, in 2018. Cells were Gram-stain-negative cocci and exhibited slow growth under standard laboratory conditions, with optimal growth at 35 °C, pH 7.5, and 1.0% NaCl. The draft genome comprised approximately 1.86 Mbp (Gen...

This study aimed to synthesize a liposomal nanoformulation containing citrinin (LP-CIT) to improve its availability and to evaluate its toxicogenomic profile, focusing on cytotoxic and genotoxic effects in breast cancer (MDA-MB-231) and non-tumorigenic mammary epithelial (MCF-10A) cell lines. The formulation was characterized by macroscopic appearance, pH, particle size, polydispersity index (PDI), zeta potential, encapsulatio...

Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

Dalbulus maidis is a key pest and vector of maize pathogens in Latin America. Understanding the field population dynamics of D. maidis is essential for improving management strategies and reducing the risk of pathogen transmission in maize. This study evaluated the population density and stage structure of D. maidis across maize vegetative stages and determined the effects of crop development and climatic variables on the abun...

Objectives Plant-derived active pharmaceutical ingredients (APIs), including crude extracts, phytocomplexes, and isolated compounds, have been extensively investigated due to their therapeutic potential. However, their pharmaceutical application is often hindered by challenges such as low solubility, limited stability, and poor bioavailability. Amorphous solid dispersions (ASDs) have emerged as a promising strategy to overcome...