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During the past century, bivalve populations across the globe have collapsed, resulting in negative ecosystem consequences due to their outsized impact on shallow estuaries. In response, there has been strong interest in the restoration of marine bivalve populations. Here, we present a decade-long restoration effort that sought to rebuild a collapsed (99.5% reduction in harvest) and recruitment-limited population of hard clams...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Representing plant diversity in land models: An evolutionary approach to make “Functional Types” more functionalNARA Subscribed
Plants are critical mediators of terrestrial mass and energy fluxes, and their structural and functional traits have profound impacts on local and global climate, biogeochemistry, biodiversity, and hydrology. Yet, Earth System Models (ESMs), our most powerful tools for predicting the effects of humans on the coupled biosphere–atmosphere system, simplify the incredible diversity of land plants into a handful of coarse categorie...
The limiting factors and regulatory processes that control the environmental responses of C3, C3–C4 intermediate, and C4 photosynthesisNARA Subscribed
Here, we describe a model of C 3 , C 3 –C 4 intermediate, and C 4 photosynthesis that is designed to facilitate quantitative analysis of physiological measurements. The model relates the factors limiting electron transport and carbon metabolism, the regulatory processes that coordinate these metabolic domains, and the responses to light, carbon dioxide, and temperature. It has three unique features. First, mechanistic expressi...
The EU chemicals strategy for sustainability (CSS) asserts that both human health and the environment are presently threatened and that further regulation is necessary. In a recent Guest Editorial, members of the German competent authority for risk assessment, the BfR, raised concerns about the scientific justification for this strategy. The complexity and interdependence of the networks of regulation of chemical substances ha...
Pelagophytes are abundant picophytoplankton within open ocean ecosystems and the causative algae of harmful brown tide blooms in estuaries. The physiological capabilities facilitating the ecological success of pelagophytes in these diverse ecosystems remains poorly understood. Here, we investigated the transcriptional response of two coastal pelagophytes ( Aureococcus anophagefferens and Aureoumbra lagunensis ) and two open oc...
Theoretically, both synthetic endocrine disrupting chemicals (S-EDCs) and natural (exogenous and endogenous) endocrine disrupting chemicals (N-EDCs) can interact with endocrine receptors and disturb hormonal balance. However, compared to endogenous hormones, S-EDCs are only weak partial agonists with receptor affinities several orders of magnitude lower. Thus, to elicit observable effects, S-EDCs require considerably higher co...
Key message Yield penalty and increased grain protein content traits associated with Aegilops ventricosa 7D introgression have been mapped for the first time, and they are physically distinct from the eyespot resistance locus Pch1. Abstract Wheat wild relatives represent an important source of genetic variation, but introgression of agronomically relevant genes, such as for disease resistance, may lead to the simultaneous intr...
Terrestrial photosynthesis is the largest and one of the most uncertain fluxes in the global carbon cycle. We find that near‐infrared reflectance of vegetation (NIR V ), a remotely sensed measure of canopy structure, accurately predicts photosynthesis at FLUXNET validation sites at monthly to annual timescales ( R 2 = 0.68), without the need for difficult to acquire information about environmental factors that constrain photos...
Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as a proof-of-concept study to demonstrate efficacy of pazopanib on HHT-related bleeding, and to measure safety....