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Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation. In this study, we present an integrated characterisation of the genomic organisation, tissue expression and dietary resp...
Under global climate change, co-occurrence of ocean acidification (OA) and warming poses a substantial threat to marine ecosystems. The present study focused on the Strait of Georgia within the Northeast Pacific region, where conditions of aragonite undersaturation exist year-round across the majority of the water column, with further intensification expected under OA. These conditions coincide with persistent rises in mean se...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Permafrost Thaw Accelerates Old Soil Carbon Release, Outpacing New Plant Inputs During a 13‐Year Tundra Warming ExperimentNARA Subscribed
Massive stores of ancient soil organic carbon (SOC) in permafrost can decompose with Arctic warming and accelerate global climate change. Declining SOC stocks are central to the permafrost carbon feedback, but direct measures of SOC loss are extremely rare due to methodological challenges related to subsidence in the Arctic. To fully capture changing SOC dynamics during thaw, we directly measured SOC stock and bulk soil radioc...
Priorities, concerns, and potential compromises amongst urban forest stakeholders: international lessons from Aotearoa New ZealandNARA Subscribed
Urban forests provide numerous benefits including habitat for wildlife, improving human health, purifying air and water, and preventing and mitigating the effects of climate change. The need to protect and improve our urban forests will only increase as populations increase and cities densify and expand over time. However, urban forest establishment and maintenance is challenging due to a lack of effective policies, delays, la...
In order to investigate how shellfish culture in the intertidal zone may serve as a means of conferring resilience prior to subtidal deployment for commercial grow-out, a common garden experiment was carried out with juvenile Pacific oysters. Individuals were cultured under intertidal or subtidal conditions for one year, following which intertidal animals were transplanted to the subtidal site and both treatment groups were cu...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Effects of snake fungal disease (ophidiomycosis) on the skin microbiome across two major experimental scalesNARA Subscribed
Emerging infectious diseases are increasingly recognized as a significant threat to global biodiversity conservation. Elucidating the relationship between pathogens and the host microbiome could lead to novel approaches for mitigating disease impacts. Pathogens can alter the host microbiome by inducing dysbiosis, an ecological state characterized by a reduction in bacterial alpha diversity, an increase in pathobionts, or a shi...
Global Marine Flyways Identified for Long‐Distance Migrating Seabirds From Tracking DataNARA Subscribed
Aim To identify the broad‐scale oceanic migration routes (‘marine flyways’) used by multiple pelagic, long‐distance migratory seabirds based on a global compilation of tracking data. Location Global. Time Period 1989–2023. Major Taxa Studied Seabirds (Families: Phaethontidae, Hydrobatidae, Diomedeidae, Procellariidae, Laridae and Stercorariidae). Methods We collated a comprehensive global tracking dataset that included the mig...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...