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A Model for Clinician and Staff Education in the Engagement of American Indians in Genomic ResearchNARA Subscribed
Despite notable differences in cancer incidence and outcomes, fewer American Indians have participated in cancer research and genomic testing relative to their population size. Contributing factors include historical scientific mistrust, lack of culturally appropriate research methodologies, and limited access. With the launch of a cancer genomic sequencing trial in American Indians from the Southwestern United States (US), cl...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
An Effective Barrier Coating Technology Against Premature Bolt Failures in Underground MinesNARA Subscribed
Significant safety and economic consequences accompany the premature failure of bolts, posing sustainability challenges for mining operations. Previous studies have indicated that hydrogen-induced stress corrosion cracking (HISCC), primarily influenced by microbial activities termed microbiologically influenced stress corrosion cracking (MISCC), stands as a major contributor to the premature failure of bolts in underground min...
Predicting and assessing the impacts of COVID-19 disruption on marine science and sectors in AustraliaNARA Subscribed
By March 2020 coronavirus disease 2019 (COVID-19) was anticipated to present a major challenge to the work undertaken by scientists. This pandemic could be considered just one of the shocks that human society has had and will be likely to confront again in the future. As strategic thinking about the future can assist performance and planning of scientific research in the face of change, the pandemic presented an opportunity to...
Population genomics of the muskox' resilience in the near absence of genetic variationNARA Subscribed
Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox ( Ovibos moschatus ), an Ice Age relict that was at t...
The EnMAP imaging spectroscopy mission towards operationsNARA Subscribed
Seagrasses are globally recognized for their contribution to blue carbon sequestration. However, accurate quantification of their carbon storage capacity remains uncertain due, in part, to an incomplete inventory of global seagrass extent and assessment of its temporal variability. Furthermore, seagrasses are undergoing significant decline globally, which highlights the urgent need to develop change detection techniques applic...
Commentary on Coram et al. (2021) on the use of Facebook to understand marine mammal stranding issues in Southeast AsiaNARA Subscribed
We reviewed Coram et al. (Biodivers Conserv 30:2341–2359, 2021, 10.1007/s10531-021-02196-6 ), a paper that highlights the use of social media data to understand marine litter and marine mammals in Southeast Asia. While we commend its intent, we find that the methodology used and conclusions drawn portray an incomplete and inaccurate perception of how strandings, stranding response, and analysis of stranding data have been cond...
Food system is a powerful concept for understanding and responding to nutrition and sustainability challenges. Food systems integrate social, economic, environmental and health aspects of food production through to consumption. Aquatic foods are an essential part of food systems providing an accessible source of nutrition for millions of people. Yet, it is unclear to what degree research across diverse disciplines concerning a...