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Investigating the effects of membrane curvature inducing proteins on lipid droplets in Saccharomyces cerevisiaeNARA Subscribed
Background Reticulons (Rtn1p, Rtn2p) and Yop1p are proteins shaping the endoplasmic reticulum (ER) membrane curvature their function being to a large degree responsible for molding the membrane curvature in the tubular ER area. Lipid biosynthesis mainly takes place in the tubular parts of the ER and lipid droplets are formed in the tubular ER membrane. Nucleation constitutes the rate-limiting step in lipid droplet formation an...
Polar Winter Processes: An Under-Represented Research Focus within the Coupled Earth SystemNARA Subscribed
Observing winter processes during the extended cold season is crucial not only for understanding polar and global coupled Earth system but also for enhancing capability of year-round prediction, especially in the context of Arctic amplification and the drastic decrease in sea ice extent and thickness at both poles. However, harsh environmental conditions and logistical challenges have left polar winter Earth system processes s...
Sporecasting Biogeography Across Scales: Continental Patterns and Local Constraints on Macrofungal DispersalNARA Subscribed
Understanding how aerial fungal diversity varies across space, habitat, and disturbance is key to linking local‐scale sporocarp (fruiting body) reproduction with continental‐scale biogeography. In this study, we combined passive spore trap metabarcoding with macrofungal sporocarp records from 31 plots in eight sites across North America to quantify how site, habitat, and fire history shape aerial macrofungal communities. From...
Increased root‐derived carbon buffers soil carbon loss under simultaneous warming and nitrogen additionNARA Subscribed
Plant roots are primary drivers of soil organic matter dynamics, mediating belowground carbon (C) inputs, stabilization, and losses. Yet, how global changes such as rising temperatures and altered nitrogen (N) availability interact to affect these dynamics has rarely been tested empirically in the field. Here, we quantify how inputs to soil organic matter from fine‐root production, root exudates, and root‐associated fungi resp...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
IND-enabling preclinical studies of [11C]COU, a trapped metabolite PET radiotracer for monoamine oxidase-BNARA Subscribed
[ 11 C]COU is a trapped metabolite radiotracer for in vivo analysis of Monoamine Oxidase B activity using positron emission tomography (PET) imaging. [ 11 C]COU has the potential to quantify astrocytosis in the early stages of Alzheimer’s disease, providing an earlier marker of disease than currently available for staging disease progression. Prior preclinical studies have demonstrated the efficacy of this radiotracer in precl...
Global warming is expected to transfer carbon from soil organic matter to atmospheric CO 2 , with microbial communities playing a crucial role in regulating this exchange. While the immediate impact of temperature on microbial functions is well understood and causes soil carbon losses, the long‐term response remains unclear, with losses stabilising over time, reducing the overall effect of chronic warming on soil organic carbo...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Nitrogen Deposition Weakens Soil Carbon Control of Nitrogen Dynamics Across the Contiguous United StatesNARA Subscribed
Anthropogenic nitrogen (N) deposition is unequally distributed across space and time, with inputs to terrestrial ecosystems impacted by industry regulations and variations in human activity. Soil carbon (C) content normally controls the fraction of mineralized N that is nitrified ( ƒ nitrified ), affecting N bioavailability for plants and microbes. However, it is unknown whether N deposition has modified the relationships amon...
Long‐Term Soil Warming Drives Different Belowground Responses in Arbuscular Mycorrhizal and Ectomycorrhizal TreesNARA Subscribed
The ability of trees to acquire soil nutrients under future climate conditions will influence forest composition and function in a warmer world. Rarely are multiple belowground carbon allocation pathways measured simultaneously in large global change experiments, restricting our understanding of how trees may shift their allocation of resources to different nutrient acquisition mechanisms under future climates. Leveraging a 20...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
Response of Root Respiration to Warming and Nitrogen Addition Depends on Tree SpeciesNARA Subscribed
Roots contribute a large fraction of CO 2 efflux from soils, yet the extent to which global change factors affect root‐derived fluxes is poorly understood. We investigated how red maple ( Acer rubrum ) and red oak ( Quercus rubra ) root biomass and respiration respond to long‐term (15 years) soil warming, nitrogen addition, or their combination in a temperate forest. We found that ecosystem root respiration was decreased by 40...