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Effects of verification stage intensity and duration on $$\dot{V}O_{{2\max }}$$ determinationNARA Subscribed
Purpose Verification stages are recommended for maximal oxygen consumption (V̇O ₂max ) determination, but there is currently no standardization of verification stage design. We sought to determine if the length of recovery and the initial intensity of subsequent exercise influence the effectiveness of verification stages during testing for V̇O ₂max . Methods Twenty-seven participants (20 males, 7 females) completed four graded...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
The functional effect of gape size on intraspecific body condition is variable across trophic groups and resource seasonalityNARA Subscribed
Gape size is a key functional trait that influences feeding performance and ecological fitness across animal taxa; yet, its role within species remains underexplored, particularly in dynamic environments. We investigated the relationship between relative gape size and condition factor ( Kn ) across 15 species of tropical freshwater fish from northern Australia, spanning four trophic groups: predators, micro-carnivores, omnivor...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The environmental drivers of fin whale (Balaenoptera physalus) acoustic presence in Eastern Antarctic waters were investigated based on passive acoustic recordings from four sites, 2013–2019. Fin whale 20 Hz pulses were detected from late austral summer to early winter. Daily values of sea-ice concentration (SIC) were compared with the number of days with fin whale 20 Hz acoustic presence using a generalized additive model app...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Using fishes as indicators of estuarine degradation is informative in long-term monitoring programs. Beach seine hauls were used in four estuaries that differed in their trophic and tidal status. The study found that inner, middle, and outer estuarine nearshore fish communities differed significantly at from all estuaries, for all sampling times. To reduce the effects of within-estuary variability, between-estuary differences...
Mathematical and statistical models underlie many of the world's most important fisheries management decisions. Since the 19th century, difficulty calibrating and fitting such models has been used to justify the selection of simple, stationary, single‐species models to aid tactical fisheries management decisions. Whereas these justifications are reasonable, it is imperative that we quantify the value of different levels of mod...
Cannabidiol is a major component of cannabis but without known psychoactive properties. A wide range of properties have been attributed to it, such as anti-inflammatory, analgesic, anti-cancer, anti-seizure and anxiolytic. However, being a fairly new compound in its purified form, little is known about cannabidiol brain entry, especially during development. Sprague Dawley rats at four developmental ages: embryonic day E19, pos...