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Infectious disease is a growing threat to wildlife, with zoonotic transmission most likely at the human–wildlife interface. One underappreciated activity at this interface is fieldwork with wild animals, but associated risks can be mitigated through field hygiene (FH) practices, such as using personal protective equipment and other appropriate behaviors. Following the dissemination of International Union for Conservation of Na...
A Framework to Investigate the Effects of Observation Error on Neural Network Predictions of Fish AgeNARA Subscribed
Technological innovations for predicting fish age represent a paradigm shift from conventional age estimation methods used in fisheries science. Recently developed secondary methods rely on models trained on conventional age estimates, derived from subjective interpretation of growth patterns and a biological property of the fish to predict age. Hence, quantifying the error that propagates from these models and the conventiona...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
The complex population structure of Tamanend's bottlenose dolphins ( Tursiops erebennus ) along the U.S. Mid‐Atlantic coast complicates assessment of their bycatch. To improve our understanding of the stock identity of individual dolphins taken as bycatch in this region, we compared images of the dorsal fins of bottlenose dolphins that stranded with evidence of fishery interactions (FI+) to the Mid‐Atlantic Bottlenose Dolphin...
Utilizing Exhaled Breath and Skin Microbiomes in Assessments of At‐Risk Killer Whales ( Orcinus orca )NARA Subscribed
For at‐risk populations of killer whales ( Orcinus orca ), biological samples can offer information about individual animal status. We hypothesized that low‐yield samples could provide sufficient material for microbiome analysis. We collected and analyzed, with amplicon metabarcoding, breath samples from managed care and free‐ranging killer whales (8 and 14 animals, respectively) and epidermal tissue from free‐ranging killer w...
Systematics of the New Zealand FloraNARA Subscribed
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Micro‐Refuges or Ecological Traps: Context‐Dependent Effects of Rock Pools on Intertidal Biodiversity Across LatitudesNARA Subscribed
Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Purpose Patch-clamping is a foundational technique in electrophysiology that requires substantial training due to its complexity and resource-intensive nature. This study evaluates the effectiveness of an interactive patch-clamping simulation in improving accessibility, skill acquisition, and educational outcomes compared to traditional training methods. Methods A virtual simulation replicating key aspects of patch-clamping wa...