The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...

Understanding how species assemble across landscapes requires integration of data representing evolutionary, ecological, and biogeographic processes. We developed a comparative macrogenetic framework, applying it across 22 co‐distributed rainforest trees, to identify replicated landscape‐level genetic signatures. Diversity‐migration analyses and genogeographic clustering identified shared spatial dynamics in relation to refugi...

Cities increasingly hope to mobilize nature-based solutions in urban sustainability planning because of their wide-ranging ecosystem services. In this critical moment, where failure due to poor implementation could lead policymakers to turn away from nature-based solutions, we investigate the case of urban forestry and ask: how do strategic-level sustainability goals influences site-level decision-making? We conducted semi-str...

Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient component resulting from activation of P2X1 receptors by ATP and a secondary sustained component mediated by activation of α 1 -adrenoceptors by noradrenaline. Noradrenaline can also potentiate the ATP-dependent contractions of the vas deferens, but the mechanisms underlying this effect are unclear. The purpose of...

C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of glycoproteins that are implicated in a broad range of physiologic processes. The group XIV subfamily of CTLDs are comprised of CD93, CD248/endosialin, CLEC14a, and thrombomodulin/CD141, and have important roles in creating and maintaining blood vessels, organizing extracellular matrix, and balancing pro- and a...

The seas of Southeast Asia are home to some of the world’s most diverse ecosystems and resources that support the livelihoods of millions of people. Climate change will bring temperature changes, acidification and other environmental change, with uncertain consequences for human and natural systems, but there has been little regional-scale climate modelling of the marine ecosystem. We present initial dynamically downscaled pro...