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Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysisNARA Subscribed
Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly patients with COVID-19. For this purpose, we employed a derivation cohort with 450 SARS-CoV-2 infected and unvaccinated patients admitted to hospital wards and a validation cohort with 244 SARS-CoV-2 infected and unvaccinated patie...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Purpose Systematic collection and analysis of antimicrobial resistance data from key bacterial pathogens is essential to contribute to control antimicrobial resistance (AMR). The aim of this work was to survey the drug resistance on clinically relevant organisms stratified according to age, gender, clinical specimens and facilities. Methods Microbiological data were collected from 55 centers across 24 states in Mexico between...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The Missing Global South in Climate Change Biology: Towards Equitable Knowledge Inclusion for Effective Global SolutionsNARA Subscribed
Over the last decades, climate change biology has become a central field in global science, yet knowledge production and its inclusion in global strategies remain profoundly unequal. Our bibliometric analysis of over 580,000 records shows that ~80% of author affiliations come from Global North institutions, meaning that research agendas, theoretical frameworks, and priorities are still largely shaped outside the regions with t...
The Strait of Gibraltar (SG) is a key biogeographic and ecological corridor connecting the Mediterranean Sea and the Atlantic Ocean, enabling the seasonal migrations of fin whales (Balaenoptera physalus). The objective of this study was to characterize, for the first time, the spatial and temporal exposure of the species to maritime traffic during its migration through the SG, quantifying movement patterns, individual composit...
Admixture Mapping Reveals Evidence for Multiple Mitonuclear Incompatibilities in Swordtail Fish HybridsNARA Subscribed
How barriers to gene flow arise between closely related species is one of the oldest questions in evolutionary biology. Classic models in evolutionary biology predict that negative epistatic interactions between variants in the genomes of diverged lineages, known as hybrid incompatibilities, will reduce viability or fertility in hybrids. The genetic architecture of these interactions and the evolutionary paths through which th...
Anchialine caves are singular aquatic environments of significant conservation interest, defined by darkness, constant temperature, and low levels of nutrients and dissolved oxygen, as well as vertically stratified water layers. Due to their challenging accessibility, these caves represent one of the few remaining unexplored frontiers on Earth, hosting short-range endemics and ecologically specialized communities highly suscep...