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Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in BrazilNARA Subscribed
Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort usi...
We have attempted to re-establish bay scallops to the Virginia, U.S.A. coastal bays and document the dynamics of the restoration effort. Bay scallops ( Argopecten irradians ) once flourished in the eelgrass ( Zostera marina ) of the Virginia coastal bays. Eelgrass wasting disease led to declines, and both eelgrass and scallops were completely lost after a 1933 hurricane. The Virginia Institute of Marine Science (VIMS) led a su...
The Effects of Land‐Use Dynamics on Avian Phylogenetic Diversity Across Island EcosystemsNARA Subscribed
Aim To test whether forest extent and recent forest‐cover change are associated with avian phylogenetic diversity and community‐level evolutionary value across islands. Location Seven islands spanning Borneo and Wallacea in the Malay Archipelago. Taxon Terrestrial birds. Methods We sampled 1410 sites (2010–2022). We calculated phylogenetic diversity (PD), mean phylogenetic distance (MPD), mean nearest taxon distance (MNTD) and...
Biological Sex Is Binary and Rooted in AnisogamyNARA Subscribed
The definition of biological sex has become a renewed focus of societal debate, fuelled by the conflation of biological principles with discussions of human gender diversity. Here, we argue that conceptual clarity critically depends on separating these domains. Drawing on evolutionary theory and empirical evidence, we maintain that biological sex is best defined as a binary classification of male and female reproductive strate...
Pathologic Description and Genetic Characterisation of Kudoa thunni From Yellowfin Tuna ( Thunnus albacares ) in the Caribbean SeaNARA Subscribed
Yellowfin tuna ( Thunnus albacares ) is a valuable recreational and commercial species in Grenada and the Caribbean region. Myxozoans, specifically the monotypic Kudoidae family within the Order Multivalvulida, are marine parasitic organisms that can negatively impact fish health and marketability. On 8 September 2023, muscle fillets from a yellowfin tuna caught off the coast of Grenada and containing numerous white nodules we...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Key message Soybean rust-associated haplotypes around significant SNPs show variable effects across diverse accessions, while distinct soybean mosaic virus-resistant haplotypes were identified at the Rsv1 locus on chromosome 13. Abstract Soybean rust (SBR), caused by the fungal pathogen Phakopsora pachyrhizi, significantly affects soybean yield and quality globally. Here, we present an association and haplotype analysis of 2,8...
Accessing crop genetic diversity via pangenomicsNARA Subscribed
With the increasing accuracy and decreasing cost of sequencing technology, the extent of structural variation (SV) and its importance in crop species has become increasingly evident. SVs such as insertions, deletions, and inversions have been associated with genetic variation of agronomically important traits and the diversification of crop species. Pangenomes aim to capture the genetic diversity of a species, population or ge...
Regional Nasal Drug Deposition in Pediatric vs. Adult Models: In vitro Insights into User Technique and Breathing Patterns SensitivityNARA Subscribed
Purpose Although in vitro studies recommended for establishing bioequivalence of locally acting nasal suspension products provide useful information regarding product performance, currently they are not designed to fully account for variability introduced by patient-specific factors such as administration technique and breathing patterns. This limitation, combined with ethical and practical challenges in conducting pediatric c...
Prevalence of traded bird species in key biodiversity areasNARA Subscribed
The use and trade of biodiversity involve tens of thousands of species that are exploited at a range of scales, intensities, and degrees of sustainability. As a result, some are highly threatened. Key biodiversity areas (KBAs) are sites of significance for the persistence of biodiversity identified nationally based on standardized criteria. The degree to which biodiversity in KBAs is likely to be used and traded is not well un...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...