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The immunogenic potential of AZD1402 (Elarekibep) T-cell epitopes in healthy volunteers and drug-exposed clinical trial participantsNARA Subscribed
AZD1402 (Elarekibep) is a novel anticalin with engineered IL-4Rα antagonist binding properties that was under development for inhaled treatment of asthma. Structural similarity to tear-lipocalin is thought to limit immunogenicity risk; however, a range of treatment-emergent hypersensitivity-like adverse events were observed in a clinical study. This study aimed to (i) explore the activation of drug-exposed human T-cells with A...
The CALHM1 blocker CGP37157 increases seizure severity during status epilepticus in adult miceNARA Subscribed
Epilepsy is one of the most common chronic brain diseases affecting up to 70 million people worldwide. Major challenges of epilepsy treatment include the high pharmacoresistance in patients and the lack of disease-modification. Extracellular adenosine 3’triphosphate (ATP), a key neurotransmitter in the activation of the purinergic signalling system, is increasingly recognized to contribute to pathological brain hyperexcitabili...
Between 1989 and 2007, 28 Distinct Population Segments (DPS) of Pacific salmon ( Oncorhynchus spp.) spawning in rivers in California and the Pacific Northwest (Oregon, Washington, Idaho) were listed (protected) under the US Endangered Species Act (ESA). In the roughly 25 years since then, considerable efforts have been made to recover these populations, but no DPS has increased sufficiently to be delisted. We evaluated abundan...
An emerging technology for building capacity to make decisions in the ocean space is the development of Digital Twins of the Ocean (DTOs). A DTO is a virtual replication of the ocean environment, including its properties, behaviors, and processes (https://www.mercator-ocean.eu/en/digital-twin-ocean/). These digital replicas are created using a combination of real-time data collected from satellites and thousands of sensor...
Soil N 2 O emissions during dry fallow periodsNARA Subscribed
Shang et al. (2024) recently suggested to include nitrous oxide (N 2 O) emissions during the fallow period to better estimate N 2 O emission factors (EFs). We however highlighted several pitfalls of the proposed adjusted EFs for croplands in the specific case of dry subhumid, semiarid, and arid regions with dry fallow periods, these regions covering about 47% of the Earth's terrestrial area.
The purpose of this study is to evaluate the direct and indirect effects of a web-based, Protection Motivation Theory (PMT)–informed breast cancer education and decision support tool on intentions for risk-reducing medication and breast MRI among high-risk women. Women with ≥ 1.67% 5-year breast cancer risk ( N = 995) were randomized to (1) control or (2) the PMT-informed intervention. Six weeks post-intervention, 924 (93% ret...
Peatland rewetting has been proposed as a vital climate change mitigation tool to reduce greenhouse gas emissions and to generate suitable conditions for the return of carbon (C) sequestration. In this study, we present annual C balances for a 5‐year period at a rewetted peatland in Ireland (rewetted at the start of the study) and compare the results with an adjacent drained area (represents business‐as‐usual). Hydrological mo...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Host‐pathogen‐environment interactions predict survival outcomes of adult sockeye salmon ( Oncorhynchus nerka ) released from fisheriesNARA Subscribed
Incorporating host‐pathogen(s)‐environment axes into management and conservation planning is critical to preserving species in a warming climate. However, the role pathogens play in host stress resilience remains largely unexplored in wild animal populations. We experimentally characterized how independent and cumulative stressors (fisheries handling, high water temperature) and natural infections affected the health and longe...
Intraspecific variation in tolerance of warming in fishesNARA Subscribed
Intraspecific variation in key traits such as tolerance of warming can have profound effects on ecological and evolutionary processes, notably responses to climate change. The empirical evidence for three primary elements of intraspecific variation in tolerance of warming in fishes is reviewed. The first is purely mechanistic that tolerance varies across life stages and as fishes become mature. The limited evidence indicates s...
Renewable cellulosic nanocomposites for food packaging to avoid fossil fuel plastic pollution: a reviewNARA Subscribed
The extensive use of petroleum-based synthetic and non-biodegradable materials for packaging applications has caused severe environmental damage. The rising demand for sustainable packaging materials has encouraged scientists to explore abundant unconventional materials. For instance, cellulose, extracted from lignocellulosic biomass, has gained attention owing to its ecological and biodegradable nature. This article reviews t...