David L. Edwards results 196
· Newest (Page 1/8, per page 25)
Author: David L. Edwards ×Clear All Filters
Search Results
Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in BrazilNARA Subscribed
Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort usi...
We have attempted to re-establish bay scallops to the Virginia, U.S.A. coastal bays and document the dynamics of the restoration effort. Bay scallops ( Argopecten irradians ) once flourished in the eelgrass ( Zostera marina ) of the Virginia coastal bays. Eelgrass wasting disease led to declines, and both eelgrass and scallops were completely lost after a 1933 hurricane. The Virginia Institute of Marine Science (VIMS) led a su...
The Effects of Land‐Use Dynamics on Avian Phylogenetic Diversity Across Island EcosystemsNARA Subscribed
Aim To test whether forest extent and recent forest‐cover change are associated with avian phylogenetic diversity and community‐level evolutionary value across islands. Location Seven islands spanning Borneo and Wallacea in the Malay Archipelago. Taxon Terrestrial birds. Methods We sampled 1410 sites (2010–2022). We calculated phylogenetic diversity (PD), mean phylogenetic distance (MPD), mean nearest taxon distance (MNTD) and...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data IntegrationNARA Subscribed
The rapid advancement of DNA sequencing technologies and computational algorithms has led to an unprecedented surge in genomic data, driven by several large-scale sequencing projects worldwide. Orthology plays a crucial role in understanding evolutionary patterns of genes and their functions. At the last Quest for Orthologs meeting (Montréal, Canada—2024), we discussed recent advances in orthology inference, with a focus on th...
Interactive effects of crop types and nitrogen sources on N2O emissions in a cool humid climateNARA Subscribed
Aims Perennial forages in rotation with annual crops can improve agricultural resilience by increasing soil organic carbon. However, how nitrogen (N) sources interact with rotation diversity to influence soil nitrous oxide (N 2 O) emissions is not well understood. Methods During three snow-free seasons, N 2 O emissions, crop yields, and ancillary variables were measured at three experimental sites with contrasting soil texture...
Production and immunogenicity of a plant-produced beak and feather disease virus vaccine in Japanese quailsNARA Subscribed
Beak and feather disease virus (BFDV), a single-stranded DNA virus, infects endangered psittacine species, including the South African Cape parrot. The disease is highly contagious and can be transmitted through contact with contaminated faeces, crop secretions, and feather and skin dander. To date, there is no vaccine or cure available for BFDV. The production of an effective vaccine depends on having a production platform an...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
A Review of Global Fisheries PerformanceNARA Subscribed
Management of fisheries is complex as it combines environmental, economic and social objectives. The relative importance of these objectives is highly debated and the best approaches to achieving good outcomes are unclear. A lack of global and multi‐dimensional data has largely precluded reviews providing comparisons of performances across systems at a large scale. We review fisheries performance by analysing outcomes over 14...