Aim It is not trivial to estimate the relative contributions of dispersal, vicariance, and range contraction in explaining the present‐day distribution of ancient clades. In this study, we aim to infer the historical biogeography of bark and ambrosia beetles using a genus‐level time‐calibrated molecular phylogeny that encompasses 70% of all described genera. We also evaluate the potential influence of external factors, such as...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...

While postglacial migration patterns have been well‐studied in plants and animals in Europe, the same is not true for microorganisms such as fungi, and it remains unclear whether fungi have followed the same postglacial migration trajectories. In this study, we infer the postglacial history of the widespread wood‐decay fungus Trichaptum abietinum in Europe. We investigate whether this fungus resided in multiple glacial refugia...

Summary Saccharomyces eubayanus is the close relative of the Lager‐brewing yeast and was firstly found in North Patagonia associated with Nothofagus trees. In recent years additional strains were found in North America, Asia and New Zealand, and genomic analyses showed the existence of two main populations of this yeast, both of them present in Patagonia. Here, we performed the most comprehensive study of S. eubayanus in Patag...

Reticulate evolution can be a major driver of diversification into new niches, especially in disturbed habitats and at the edges of ranges. Industrial fermentation strains of yeast provide a window into these processes, but progress has been hampered by a limited understanding of the natural diversity and distribution of S accharomyces species and populations. For example, lager beer is brewed with S accharomyces pastorianus ,...