Background Chronic inflammatory pain is associated with persistent sensory and immune dysregulation. We evaluated the therapeutic efficacy of two cannabinoids formulations—Cannabigerol (CBG) and Standardized Full-Spectrum Cannabis Extract (FULL) in a preclinical model of acute and Chronic inflammatory pain and examined their effects on peripheral and central inflammatory mediators. Methods Cannabinoid analgesic effects were as...

Atta robusta is a narrow endemic leaf-cutting ant restricted to restinga habitats along Brazil’s southeastern coast. Despite its conservation status, little is known about its evolutionary history and genetic structure. Here, we investigate patterns of genetic variation in A. robusta using mitochondrial (COI–IGS–tRNALeu–COII) and nuclear (EF1alpha copy one) DNA markers sampled across its known range. We assess genetic diversit...

Dengue is an arboviral disease of high public health relevance, characterized by pronounced temporal variability, nonlinearity, and recurrent outbreaks, which pose challenges to epidemiological surveillance and decision-making. This study evaluated the performance of machine learning methods for short-term forecasting of the weekly dengue morbidity rate in the 27 Brazilian capital cities, comprising the 26 state capitals and B...

This study aimed to evaluate the effect of topical application of a mouth gel formulation containing iron tetracarboxyphthalocyanine (FeTcPc) during non-surgical periodontal treatment. Forty-seven individuals with periodontitis underwent a standard periodontal treatment (scaling and root planing), followed by adjuvant therapy according to the = groups: Vehicle Group ( n = 15), receiving local application of the FeTcPc gel vehi...

Flow rates for applying nutrient solutions in hydroponic systems are empirically known, yet uncertainties remain regarding whether brackish water affects the optimal flow rate and, consequently, biomass production and allocation. This study evaluated whether variations in application flow rate affect coriander biomass when brackish water is used to prepare the nutrient solution. Two consecutive greenhouse cycles were conducted...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

This study evaluated partially mixed ration (PMR) silages based on banana leaves alone (BL-PMR) or combined with tomato agro-industrial residue (BLTR-PMR) in diets of lambs managed under semi-arid conditions. Twenty-seven female lambs were assigned to three treatments during a 52-day trial (12 days adaptation; 40 days data collection): control (concentrate), BL-PMR, or BLTR-PMR. Animals grazed deferred pasture from 09:00 to 15...

The consumption of vegetables is essential for human health. However, in regions affected by mining activities, this practice may pose serious risks due to potential heavy metal contamination at the soil–plant interface. This study evaluated the phytotoxicity and metal mobility in lettuce cultivated in mine tailing-contaminated soils after the Córrego do Feijão dam failure (Brumadinho, Minas Gerais, Brazil). The increase in so...

Our objective was to evaluate the impacts of the treatment of banana leaf hay with levels of sodium hydroxide (NaOH) on intake, digestibility, feeding behavior, and blood parameters of sheep. Five ½ Santa Ines × Dorper sheep with body weight of 38.43 ± 4.38 kg were used in a Latin square design. Treatments were based on levels of NaOH in banana leaf hay, as follows: 0; 1.25; 2.5; 3.75 and 5%. Overall, the intakes of dry matter...

In this study, we investigated the taxonomic identity and biotechnological potential of the actinobacterium Streptomyces sp. LaBMicrA B280, isolated from the rhizosphere of Inga edulis (Mart.). Our approach combined a phylogenomic approach, annotation of metabolic subsystems and biosynthetic gene clusters (BGCs), biological assays to assess antifungal, antimalarial, cytotoxic, and larvicidal activities, classical molecular net...