This study aimed to synthesize a liposomal nanoformulation containing citrinin (LP-CIT) to improve its availability and to evaluate its toxicogenomic profile, focusing on cytotoxic and genotoxic effects in breast cancer (MDA-MB-231) and non-tumorigenic mammary epithelial (MCF-10A) cell lines. The formulation was characterized by macroscopic appearance, pH, particle size, polydispersity index (PDI), zeta potential, encapsulatio...

Objective To evaluate whether patients with RLS have increased odds of ED compared with non-RLS controls. Methods We conducted a systematic review and meta-analysis analyzing the odds of ED in patients with RLS. We included studies that: (i) evaluated adults with a diagnosis of RLS established by the pre-established criteria; (ii) included a control group without RLS; and (iii) evaluated outcomes related to the odds of ED in p...

Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...

Aluminum (Al) toxicity is the main factor limiting agricultural production in acidic soils around the world. In this scenario, melatonin (MET) has emerged as a promising approach to alleviate Al toxicity. Thus, we investigated morphophysiological responses of Pfaffia glomerata (Spreng.) Pedersen, a medicinal plant, to Al toxicity and MET application. Plants were grown in vitro for 40 days in MS medium (control) supplemented wi...

In southeastern Brazil, capybaras ( Hydrochoerus hydrochaeris ) are main hosts of the ticks Amblyomma dubitatum and Amblyomma sculptum ; the latter has great medical importance for being the main vector of Rickettsia rickettsii , the agent of Brazilian spotted fever (BSF). This study aimed to quantify ticks in areas invaded and not invaded by exotic plants ( Hedychium coronarium , Cenchrus purpureus or Megathyrsus maximus ) wi...

Mycoacaricides represent a promising alternative for managing resistant tick populations. This study evaluated the efficacy of corn oil–based Cordyceps javanica formulations against non-parasitic stages the southern cattle tick Rhipicephalus microplus under laboratory and semi-field conditions. Additionally, fungal persistence in soil and possible alterations in soil composition were assessed using ATR-FTIR spectroscopy combin...

This study assessed the functional potential of autochthonous lactic acid bacteria isolated from the gastrointestinal tract of tambaqui ( Colossoma macropomum ) as larviculture probiotics. Five strains were selected and identified as belonging to the genus Weissella . In vitro assays revealed high tolerance to acidic pH (2.0–3.0), resistance to bile salts (10%), biofilm formation capacity, hydrophobicity and direct Aeromonas h...

Fungal infections have emerged as a significant public health concern, especially with the increasing incidence of severe mycoses caused by pathogens such as Aspergillus fumigatus , Candida auris , Candida albicans , and Cryptococcus neoformans . These fungi, listed as critical priorities by the World Health Organization, pose a heightened risk due to rising antifungal resistance and their severe impact on immunocompromised in...

The massive influx of pelagic Sargassum spp. species, also known as Sargassum inundation events (SIEs), first arrived at the Caribbean’s coastal waters in 2011. These events have been linked to hypoxia, among other ecological disturbances. Here, we report data from 2022 on (1) an assessment of the relative magnitude of particulate organic carbon (POC) load arising from SIEs into the La Parguera Marine Reserve (LPMR) basin off...

Aim Grass‐yellow butterflies ( Eurema ) are a group of pantropical Pieridae distributed throughout Asia, Australasia, Africa and the New World. However, little is known about their diversification, including the biogeographic mechanism(s) explaining their circumglobal distribution. We present the first densely sampled, time‐calibrated phylogeny and biogeographic reconstruction of grass‐yellows to confirm the monophyly of the g...