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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Governance Arrangements That Fit Social‐Ecological Context Are Associated With Fishery SustainabilityNARA Subscribed
In many parts of the world, natural resources are primarily managed by governance arrangements at the local level. Those arrangements range from collective, such as cooperatives and associations, to individualistic, such as patrons and owner‐operators. A key question is how such arrangements influence resource use and associated social and ecological outcomes. We hypothesize that sustainable resource use is not associated with...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Adventively established Leptopilina japonica: a new opportunity for augmentative biocontrol of Drosophila suzukiiNARA Subscribed
The invasive spotted-wing drosophila, Drosophila suzukii , has emerged as a significant global pest over the past decade, threatening fruit production worldwide. The parasitoid Leptopilina japonica , presumed native to East Asia, has established adventive populations in Europe and North America and is increasingly recognized for its ability to parasitize substantial proportions of D. suzukii larvae across diverse habitats. Her...
Host‐Microbiome Associations in Livebearing Fishes Adapted to Toxic Environments Rich in Hydrogen SulfideNARA Subscribed
Organisms inhabiting extreme environments must tolerate a variety of physiochemical stressors. In some cases, host‐associated microbial communities facilitate the survival of their hosts in extreme environments, but extremophile symbioses have not been identified in vertebrates. We used 16S rRNA amplicon sequencing to investigate commonalities and differences in the gut bacterial communities of livebearing fishes ( Poecilia me...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
To address the national need to diversify the geosciences, we created the cohort-based Environmental Science Pathways Scholars Program, or E(SP)2, for undergraduates in the Environmental Science Department at Barnard College who identify as Black, Indigenous, and people of color (BIPOC), first generation, or low income. By fostering a more inclusive community in the particularly formative stages of academic and early professio...
Enacting boundaries or building bridges? Language and engagement in food-energy-water systems scienceNARA Subscribed
Scientific study of issues at the nexus of food–energy–water systems (FEWS) requires grappling with multifaceted, “wicked” problems. FEWS involve interactions occurring directly and indirectly across complex and overlapping spatial and temporal scales; they are also imbued with diverse and sometimes conflicting meanings for the human and more-than-human beings that live within them. In this paper, we consider the role of langu...