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Particulate trace elements (pTEs) play key roles in marine biogeochemical cycles through their involvement in particle-seawater exchange processes and potential roles as micronutrients for the growth and functioning of phytoplankton. Here, we report on the distributions of labile and refractory particulate gallium (Ga), germanium (Ge), beryllium (Be), tellurium (Te), tin (Sn), antimony (Sb), strontium (Sr), and thallium (Tl) a...
Multi‐Decadal Dynamics of Wetland Methane Emissions Revealed by Knowledge‐Guided Machine LearningNARA Subscribed
Measurement of methane fluxes (FCH 4 ) from natural systems, such as wetlands, has lagged far behind carbon dioxide fluxes. Short and fragmented wetland FCH 4 data limit our ability to assess its long‐term dynamics and potential climate feedbacks. Extrapolating short‐term FCH 4 records to recent decades remains challenging for both process‐based models and data‐driven machine learning (ML) approaches. Here, we develop a knowle...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C DiseaseNARA Subscribed
Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...
Neural bottlenecks: axon count, distribution, and conduction in the Manduca sexta neck connectiveNARA Subscribed
Large flying insects precisely control fast maneuvers, a demanding task made more difficult by the limitation that all information between the brain and body is transmitted through a single transmission line, the neck connective. Despite this neuroanatomical structure constraining both the amount and timing of all information between the brain and body, little is known about how severe these bottlenecks are. We sought to under...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...