Background and aims European wheat production faces the challenge of maintaining yields while reducing environmental impacts from agrochemicals. Organic farming is often considered a sustainable alternative to promote soil health and reduce chemical inputs. This study assessed nutrient status in wheat soils across nine European pedoclimatic zones, comparing conventional and organic systems and evaluating management practices s...

Purpose Quizartinib pharmacokinetics in FLT3-ITD negative acute myeloid leukemia (AML) remain largely unexplored. This study aims to validate a population pharmacokinetics model (popPK) for quizartinib in plasma samples of FLT3-ITD negative AML patients. To do so, an ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method has been developed and validated for the quantification of quiza...