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The autosomal dominant multisystemic Alagille Syndrome (ALGS) is an important cause of pediatric cholestasis. ALGS is associated with pathogenic variants in JAGGED1 (JAG1) or NOTCH2, ligand and receptor components of the Notch-signaling pathway, respectively. The detected missense variants are commonly classified as variants of uncertain significance, hindering ALGS diagnosis. To overcome this issue, we have developed a CRISPR...
Semi‐Natural Habitats Buffer the Effects of Crop Diversification on Arthropod Pest Control Services in Agricultural LandscapesNARA Subscribed
Crop diversification is a promising strategy to strengthen pest control services in agricultural landscapes. Diversifying crops may limit pests through host crop dilution or by enhancing top‐down control by their enemies. However, crop diversification may also benefit generalist pests through higher resource continuity. Using a large‐scale dataset encompassing 742 landscapes across 13 countries, we assessed the impact of lands...
Translocations and reintroductions aim to improve the viability of isolated populations and promote connectivity for large carnivores. However, there is no established framework for assessing their success. We used the Eurasian lynx ( Lynx lynx ) in western and central Europe to assess the impact of translocations on the viability of six populations and their interconnectivity. Lynx populations are small and isolated and have...
Mulch-Driven Tolerance in Potatoes: A Climate Adaptation Tool for Enhanced Yields and Plant Defence under Drought Stress ConditionsNARA Subscribed
Climate change increasingly threatens potato production through intensified drought stress and emergence of vector-transmitted diseases. This study evaluated straw mulch application as a dual-purpose climate adaptation strategy to enhance potato performance under drought conditions and reduce the incidence of bacterial potato tuber wilt (BPW) caused by ‘ Candidatus Arsenophonus phytopathogenicus’ and ‘ Candidatus Phytoplasma s...
Temperature affects the development of the pine bark beetle Ips acuminatus and the growth of its most common fungal associatesNARA Subscribed
Bark beetles play a key role in shaping forest ecosystems, and some species are among the most significant disturbance factors in coniferous forests of the Northern Hemisphere. Their ability to successfully infest living trees is closely linked to mutualistic relationships with microorganisms that help to overcome host defences or provide essential nutrients. For a deeper understanding of the effects of climate change-related...
Ongoing and future climate change impacts call for climate-resilient development that integrates adaptive and mitigative approaches. Climatic and non-climatic shocks, which are rare and disruptive events, might promote transformative changes and effectively improve climate resilience. Following the IPCC’s concept of Climate Resilient Development Pathways (CRDPs), we use document analysis and semi-structured interviews with n =...
The Critical Role of Coefficients: Updating Allometric Normalisation Constants for Modern Ecology and ModellingNARA Subscribed
Allometry, the scaling of traits or biological rates with body mass, is central to a wide range of ecological research including dynamic food web modelling. There has been extensive focus on exponents (3/4 scaling laws), but little on the coefficients (normalisation constants). Coefficients that have been used since 2006 are derived from limited data and dated methodologies. Here, we compiled a data set of over 1000 genera wit...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Purpose of Review Forests produce timber, mitigate climate change and provide important habitats; yet their capacity to provide these services under rapid global change is uncertain. “Closer-to-nature” forest management (CNFM) has been proposed by the EU Forest Strategy as a way to reconcile competing demands on forests while enhancing their resilience, but experiences with its implementation remain limited. We synthesized exp...
Background and aims Shrubs like Vaccinium vitis-idaea substantially contribute to forest carbon (C) sequestration. Therefore, understanding their allocation patterns under climate change is crucial. We conducted a translocation experiment with 13 CO 2 pulse-labelling to test if (I) belowground pools accumulate total and recently assimilated C, (II) within fine roots, assimilated C is preferentially allocated to root tips and m...