Fresh groundwater resources in coastal regions are vital for modern society, but are under considerable pressure due to population growth, seasonal peaks in demand, pollution and climate change. In recent years, interest in offshore freshened groundwater (OFG) has surged, as potential resource for addressing these challenges. Recent studies have documented OFG occurrences on many continental margins and islands, with global vo...

Immunogenicity of monoclonal antibodies (mAbs) and other biotherapeutics remains a significant clinical challenge. The resulting anti-drug antibodies (ADAs) can neutralize the drug, accelerate its clearance, diminish efficacy, and potentially trigger hypersensitivity reactions via the formation of immune complexes (ICs). Current pharmacokinetic (PK) and ADA assays typically measure the drug or ADAs but provide limited informat...

Motivation Geographic occurrences are essential for biodiversity studies, but publicly available repositories like GBIF often contain errors and biases, especially for taxonomically complex groups like Carex L. (Cyperaceae). This work provides an expert‐curated global dataset of occurrences compiled from different sources to enhance data accuracy and usability. The final dataset includes 384,067 occurrences of 1790 Carex speci...

With Next Generation Sequencing, technical advances in the field of nucleic acid sequencing enabled access to the entire transcriptome of organisms. However, the variety of information available in RNA-seq data exceeds mere sequence information. Specific RNA molecules, as well as their modification patterns or their spatial structure, can be addressed using customized biochemical and bioinformatic methods, providing deep insig...

Climate change effects on coastal ecosystems vary on large spatial scales, but can also be highly site dependent at the regional level. The Wadden Sea in the south-eastern North Sea is warming faster than many other temperate coastal areas, with surface seawater temperature increasing by almost 2 °C over the last 60 years, nearly double the global ocean mean increase. Climate warming is accompanied by rising sea levels, which...

The clinical use of therapeutic monoclonal antibodies (mAbs) for the treatment of cancer, inflammation, and other indications has been successfully established. A critical aspect of drug-antibody pharmacokinetics is immunogenicity, which triggers an immune response via an anti-drug antibody (ADA) and forms drug/ADA immune complexes (ICs). As a consequence, there may be a reduced efficacy upon neutralization by ADA or an accele...

Fire–vegetation feedbacks potentially maintain global savanna and forest distributions. Accordingly, vegetation in savanna and forest ecosystems should have differential responses to fire, but fire response data for herbaceous vegetation have yet to be synthesized across biomes. Here, we examined herbaceous vegetation responses to experimental fire at 30 sites spanning four continents. Across a variety of metrics, herbaceous v...