F. Luca results 529
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COVID-19 vaccination shifts neutrophils toward a mixed activated and regulatory phenotype in patients with severe diseaseNARA Subscribed
Background Dysregulation of the innate immune response to SARS-CoV-2 has been linked to poor outcomes in COVID-19. Neutrophils are key players in this response, displaying distinct functional profiles associated with disease severity. This study investigates how neutrophil phenotypes, and their mediators are modulated in severe COVID-19 following vaccination. Methods and Results We conducted an observational case-control study...
Associations of host gene expression in the brain, liver, muscle with fecal and cecal microbiota composition in pigsNARA Subscribed
Understanding the genetic regulation underlying host–microbiota interactions is key to elucidating how microbial communities influence host metabolism, immunity, and physiology. In this context, the main objective of this study was to integrate genomic, transcriptomic, and microbial data to identify shared regulatory variants, highlight key microbial taxa, and prioritize biological pathways related to lipid metabolism, immune...
Inhabiting the host: ectoparasites and Vector-Borne pathogens in Phyllostomidae bats within urban forest fragmentsNARA Subscribed
While bats are known to harbor various viruses and bacteria, their role as hosts for hemoparasites has not been extensively studied. This research investigated the presence of ectoparasites and vector-borne pathogens—including Anaplasmataceae agents, hemoplasmas, apicomplexans, and kinetoplastids—in 74 Phyllostomidae bats sampled from an urban forest fragment in southeastern Brazil. Overall, 31.1% of the bats were infested wit...
Antimicrobial and antibiofilm activity of selected flavonoids against pathogenic Leptospira speciesNARA Subscribed
Leptospirosis is a widespread zoonotic disease where biofilm formation significantly hinders treatment, contributing to chronic infections. This preliminary study evaluated the antimicrobial and antibiofilm properties of four flavonoids—apigenin, xanthohumol, quercetin, and luteolin—against Leptospira santarosai (sv. Guaricura), L. interrogans (sv. Copenhageni and Hardjoprajitno), and L. borgpetersenii (sv. Hardjobovis). Using...
The Missing Branches of the Bee Tree of Life: Addressing Global Darwinian Shortfalls and Their DriversNARA Subscribed
Aim Estimate the Darwinian shortfall (i.e., the lack of knowledge about phylogenetic relationships) of bees worldwide, as well as identify their drivers. Location Global. Taxon Bees (Hymenoptera, Anthophila). Methods We built phylogenies for over 12,000 bee species, combining the most comprehensive phylogeny and an algorithm with random solutions to insert missing lineages. The Darwinian shortfall was quantified as the Phyloge...