Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febrile illness to severe, life-threatening complications. In the absence of specific antiviral therapies, the development of novel treatment strategies is crucial. This study evaluates the in vivo antiviral efficacy of 2-BFU, a 2′-α-fluoro,2′-β-bromouridine monophosphate prodrug, in a murine model of DENV Seroty...

Mitochondrial dysfunction plays a critical role in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). It has been proposed that mitochondrial unfolded-protein response (UPR mt ) activation improves mitochondrial function in the liver. Growing evidence demonstrates that physical exercise effectively prevents and treats MASLD. However, the effects of exercise on UPR mt activation in the liver ar...

Conventional bivalve depuration protocols may compromise organoleptic and nutritional quality, largely as a consequence of fasting. This study investigates an innovative post-depuration feeding strategy in the clam Ruditapes decussatus using microencapsulated diets containing Nannochloropsis sp. supplemented with either a standard dose of vitamins C and E (MV) or a high dose—4× the standard level—of these vitamins (MV+). A thr...

Dunaliella salina is one of several carotenoid sources that have been considered to enhance gonad coloration in sea urchins, although its relatively high cost may limit routine use in commercial echinoculture. Identifying the minimum feeding duration required to achieve optimal results may offer a cost-effective strategy. This study evaluated a cold-extruded diet supplemented with 1.5% D. salina (DUN) as a finishing diet for P...

The subfamily Aleocharinae (Coleoptera: Staphylinidae) comprises the most diverse lineage of beetles associated with eusocial insects, yet a large portion of its termitophilous diversity remains undocumented, particularly in the Neotropical region. Here, we describe Guaranguera zilbermani gen. et sp. n., a new termitophilous rove beetle discovered in nests of Cornitermes cumulans (Kollar, 1832) (Termitidae: Syntermitinae) in s...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

During production, fish are exposed to multiple environmental, physiological, and physical stressors, which compromise development, productivity, and welfare and urge the implementation of effective and safe stress-mitigating strategies, particularly during early developmental stages. Larval zebrafish (Danio rerio) constitute a powerful model for studying acute stress responses due to the numerous advantages they offer, such a...

Advancing lignocellulose biorefining is imperative for the deployment of cellulosic (2G) biofuels. This work investigates the tailoring of the alkaline deacetylation and mechanical refining (DMR) pathway for the bioconversion of sugarcane bagasse. Experiments are conducted at laboratory and pilot scales, varying the pretreatment conditions (70–92 °C; 48–100 g NaOH /kg) and the mechanical refining technologies (PFI and disk ref...