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Isatin–pyridine oxime hybrids as potential reactivators of A-242-inhibited acetylcholinesteraseNARA Subscribed
Three new isatin–pyridine-2-oxime hybrids (AM01–03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, the interactions of these molecules within the AChE/A-242 complex were assessed through docking and molecular dynamics (MD) simulations....
Silymarin and L-carnitine are individually used in fish diets, yet whether they exert interactive or additive effects when combined remains unclear. This study aimed to investigate the individual and combined impacts of dietary silymarin (S), L-carnitine (LC), and their combination (S + LC) on growth performance, digestive enzyme activity, antioxidant status, immune response, and gene expression in Nile tilapia. A total of 360...
This study evaluated the effects of biofloc technology (BFT) on male and female red tilapia ( Oreochromis spp.) broodstock over a long-term rearing period, focusing on the pre-spawning and spawning phases. A total of 1000 mixed-sex acclimated fingerlings (36.88 ± 3.44 g) to 18 parts per thousand salinity over 15 days were assigned to either BFT or clear water control tanks. During the pre-spawning phase, BFT enhanced water qua...
This study investigated the effects of different forms of dietary vitamin C on growth performance, immune responses, antioxidant defense, and physiological health of grey mullet ( Liza ramada , mean initial weight 40.32 ± 0.15 g, n = 3) over a 60-day feeding trial. Five experimental diets were formulated: a control diet devoid of vitamin C (D1) and diets supplemented with 200 mg/kg of crystalline vitamin C (L-ascorbyl-2-monoph...
The use of agricultural waste in animal production has gained global interest. An eight-week trial was conducted to investigate the impacts of adding ethanolic guava leaf extract (GLE) as a feed supplement on the growth, feed utilization, immune response, nutrient digestibility, redox regulation, and blood health of growing rabbits. Ninety weaned growing rabbits were randomly assigned to three groups. The first group was fed a...
This study investigated the effects of dietary garlic powder and fermented garlic powder supplementation at 1% and 2% levels on growth performance, digestive tract efficacy, blood biochemistry, immunity, and antioxidant status of Liza ramada (n = 225 fish; 86.00 ± 0.42 g) over a 60-day period. Fish fed diets supplemented with both forms of garlic at both levels exhibited significantly improved final body weight, weight gain, s...