Dengue virus (DENV) infection remains a major global health concern, with clinical manifestations ranging from mild febrile illness to severe, life-threatening complications. In the absence of specific antiviral therapies, the development of novel treatment strategies is crucial. This study evaluates the in vivo antiviral efficacy of 2-BFU, a 2′-α-fluoro,2′-β-bromouridine monophosphate prodrug, in a murine model of DENV Seroty...

The Paraguayan hairy dwarf porcupine ( Coendou spinosus , Cuvier, 1823) is a rodent species (Rodentia, Erethizontidae) widely distributed in the Brazilian Atlantic forest. However, little is known about their viral diversity. In this study, we aimed to evaluate, using high-throughput sequencing (HTS), the virome of the feces of seven healthy adult free-living porcupines from Silva Jardim, Rio de Janeiro, Brazil. Total viral nu...

Rhodococcus equi is an important bacterium that affects foals up to six months of age, especially those that are immunocompromised. The main manifestation is pyogranulomatous pneumonia; nevertheless, extrapulmonary lesions have not only been reported, but are not uncommon, including arthritis and osteomyelitis. Despite the widespread occurrence of rhodococcosis, the macro- and microscopic lesions in the musculoskeletal system...

Aim Estimate the Darwinian shortfall (i.e., the lack of knowledge about phylogenetic relationships) of bees worldwide, as well as identify their drivers. Location Global. Taxon Bees (Hymenoptera, Anthophila). Methods We built phylogenies for over 12,000 bee species, combining the most comprehensive phylogeny and an algorithm with random solutions to insert missing lineages. The Darwinian shortfall was quantified as the Phyloge...

Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by progressive muscle degeneration, and the mdx mouse has been widely used to investigate disease mechanisms and therapeutic strategies, including the impact of different exercise modalities and sex-related responses on dystrophic muscle. This study compared moderate/low-intensity swimming and loaded ladder-climbing in male and female mdx, including s...