Urban stormwater runoff is an important pathway for transporting microplastics (MPs) from urban environments to marine ecosystems. However, studies investigating how socio-spatial characteristics influence MP abundance and composition remain scarce, particularly in South America. This study evaluated the influence of population density and land use on MP abundance and morphology in stormwater runoff in the coastal zone of Fort...

Obesity and endocrine disruptors (EDs) promote endoplasmic reticulum (ER) stress, a mechanism associated with cardiovascular diseases. Among EDs, BPS is widely used in consumer products. Whether BPS promotes cardiac ER stress, either alone or combined with a high-fat diet, remains unclear. Male C57BL/6 mice were assigned to a standard chow diet (SC—15 kJ/g), SC+BPS (SCB), high-fat diet (HF—21 kJ/g), or HF+BPS (HFB), receiving...

Understanding how multiple interacting stressors modulate aquatic community dynamics is fundamental to forecasting ecosystem trajectories under accelerating global change. In subtropical basins, the concurrent influences of thermal regimes, ionic composition, and habitat structure generate nonlinear and often synergistic ecological responses that remain unresolved. In this study, we integrated community-level indicators with m...

Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

In the northeast region of Brazil, melon production has been affected by root diseases caused by Macrophomina species. This study aimed to analyse the influence of inoculation methods using three Macrophomina species ( M. phaseolina , M. pseudophaseolina , and M. euphorbiicola ) on the expression of symptoms of root rot and branch decline in melon plants. Two inoculation methods were evaluated in greenhouse experiments: (1) in...

Introduction Vancomycin is an antimicrobial agent for treating central nervous system (CNS) infections caused by Gram-positive bacteria. Due to practical and ethical reasons, it is difficult to evaluate vancomycin exposure in cerebrospinal fluid (CSF) and its relationship with therapeutic outcomes. Therefore, alternative methodologies are required. We developed a physiologically based pharmacokinetic (PBPK) model to characteri...