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The anesthetic management of female dogs with mammary neoplasia, usually classified as ASA II and undergoing invasive procedures such as mastectomy and ovariohysterectomy, requires effective sedation and anesthetic stability due to the increased anesthetic risk associated with advanced age and underlying disease. In this context, this study aimed to evaluate the sedative effects and reduction in anesthetic requirements of a fu...
Endoplasmic reticulum stress is associated with cardiac effects of bisphenol S independently of a high-fat dietNARA Subscribed
Obesity and endocrine disruptors (EDs) promote endoplasmic reticulum (ER) stress, a mechanism associated with cardiovascular diseases. Among EDs, BPS is widely used in consumer products. Whether BPS promotes cardiac ER stress, either alone or combined with a high-fat diet, remains unclear. Male C57BL/6 mice were assigned to a standard chow diet (SC—15 kJ/g), SC+BPS (SCB), high-fat diet (HF—21 kJ/g), or HF+BPS (HFB), receiving...
Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...
Cetaceans face multiple threats, and pollution has become a major concern for their conservation worldwide. This study assessed metal(loid) concentrations in the tissues of two odontocete species with coastal and oceanic habits, namely Guiana dolphin ( Sotalia guianensis ; n = 11) and the false killer whale ( Pseudorca crassidens ; n = 8), respectively, stranded along the northeastern Brazilian equatorial margin. Silver (Ag),...
Increasing prevalence of Alzheimer’s disease, driven by population aging, highlights the need to investigate its underlying molecular mechanisms. Within this context, long non-coding RNAs (lncRNAs) have emerged as a key regulatory layer. To advance the understanding of lncRNA dysregulation and function during Alzheimer’s disease progression, we reanalyzed publicly available single-nucleus RNA sequencing (snRNA-seq) datasets. T...