Fernando Alonso results 109
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Purpose Complicated urinary tract infections (cUTIs) are a frequent indication for admission to Hospital-at-Home (HaH) and outpatient parenteral antimicrobial therapy (OPAT) programmes. We describe the clinical, urological and microbiological profile, antimicrobial treatment and outcomes of a cUTI cohort managed in a HaH unit, and explored, in an exploratory analysis, factors associated with the 30-day composite of unplanned r...
Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implantNARA Subscribed
Knee osteoarthritis (OA), a degenerative joint disease, is increasingly prevalent worldwide and often results from a meniscal deterioration that leads to meniscus removal. Replacing the damaged meniscus with a non-biodegradable prosthesis offers an innovative solution to prevent OA progression, particularly in older patients. However, the long-term use of anti-inflammatory drugs for pain relief and prosthesis integration can c...
Aim Microbiome rewilding seeks to harness plant‐microbe interactions for sustainable agriculture, assuming that ancestral microbial partners have been lost during domestication and geographical spread. Designing microbiome rewilding strategies requires a quantitative and predictive understanding of the fundamental ecological processes—selection, dispersal, and drift—driving microbial assembly and persistence in the rhizosphere...
Cortical volumetry and longitudinal cognitive changes in Parkinson’s disease: insights from the COPPADIS cohortNARA Subscribed
Cognitive decline is a major non-motor symptom in Parkinson’s disease (PD), often linked to brain atrophy. This study examines the relationship between cortical atrophy and age groups in predicting cognitive decline in PD over five years. 188 PD patients from the COPPADIS cohort were stratified by age: young (30–55 years, N = 47), middle-aged (56–65 years, N = 59), and older adults (66–75 years, N = 82). Baseline cortical volu...
Bayesian Stochastic Rainfall Generator (BSRG): Intelligent and Digital tool for Rainfall Forecasting through Bayesian Causal ModellingNARA Subscribed
Rainfall is probably the most uncertain natural variable. This research is mainly aimed to design an intelligent data-driven tool called Bayesian Stochastic Rainfall Generator (BSRG) for improving the rainfall forecast. There are several previous stochastic generators for rainfall data generation. However, there is not any designed through a Bayesian stochastic approach. The utilization of rainfall data from the Muñogalindo ra...
Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndromeNARA Subscribed
The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55–75 years in men and 60–75 years in women) who exhibited overweight/obesity and metabolic syndrome. Data...