There are challenges that require collaboration among researchers to ensure that tobacco harm reduction strategies are evidence-based. A key challenge is evaluating the safety of flavors in e-cigarettes. Many flavorings are deemed “generally recognized as safe” (GRAS) for ingestion, but this does not guarantee their safety when inhaled. The Replica international research group is dedicated to the replication of studies on toba...

This systematic review examines the prevalence, underlying mechanisms, cohort characteristics, evaluation criteria, and cohort types in white matter hyperintensity (WMH) pipeline and implementation literature spanning the last two decades. Following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we categorized WMH segmentation tools based on their methodologies from January 1, 2000, to...

While surface station observations of downwelling radiation offer accuracy at high temporal resolution, they do not easily allow an evaluation of model surface radiation budgets (SRB) over a wide geographical area. We evaluate three gridded SRB data sets against detailed observations from six surface radiation sites from the US surface radiation (SURFRAD) network. We subsequently use the most accurate surrogate observational d...