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Electronic cigarette (e-cigarette) use continues to rise, yet the toxicological mechanisms by which inhaled aerosols impair airway epithelial integrity remain poorly defined. E-cadherin, a key adherens junction protein required for epithelial cohesion, can undergo proteolytic cleavage to generate soluble E-cadherin (sE-cad), a mediator of epithelial barrier dysfunction and inflammation. We hypothesized that e-cigarette aerosol...
Reliable developmental benchmarks are essential for synchronizing incubation and first-feeding decisions in striped bass (Morone saxatilis) hatcheries, yet existing references are incomplete, outdated, or difficult to apply across variable temperature regimes. We developed contemporary embryo and larval developmental staging guides for striped bass using digital imaging and degree day standardization and paired these guides wi...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership of scientists and practitioners called the Shorebird Science and Conservation Collec...
Who needs closure? Estimating abundance with a Markovian availability model for geographically open removal samplingNARA Subscribed
Removal sampling is an important method for estimating abundance, but nearly all removal models assume closure during sampling. Yet, closure may be difficult to assume, evaluate, or enforce in many settings. To address situations where populations are geographically open between each removal sample, we incorporated a Markovian availability process into an N‐mixture model framework. This model relates local abundance available...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...