Gordon C. results 387
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Lead fractionation and availability in contaminated soils: a comparative study of organic wastes and zeolite as stabilizing agentsNARA Subscribed
Lead (Pb) contamination in soils is a major environmental concern due to its persistence, toxicity, and bioaccumulation. This study evaluated the effects of organic amendments (sewage sludge, cattle manure, and poultry manure) and zeolite with different particle sizes (< 0.4, 2–8, and > 8 mm) applied at 1, 5, and 10% (v/v) on Pb mobility and availability in soil contaminated with Pb-rich mine tailings. Soil pH and acid-labile...
Discovery of a Potent Small Molecule Antagonist of GRPR for the Treatment of PruritusNARA Subscribed
Persistent pruritus (itch) affects the quality of life, and many itch syndromes remain untreatable. Previously, we identified the gastrin-releasing peptide receptor (GRPR) playing a critical role in mediating histamine-independent itch signaling. In this study, we aimed to identify small-molecule GRPR antagonists to treat histamine-independent itch. Starting with the known small-molecule GRPR antagonist PD 176,252, we conducte...
Modeling of gene regulatory networks: an annotated glossaryNARA Subscribed
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
Does acute stress induced via cold water immersion increase blood THC concentrations in regular cannabis users?NARA Subscribed
Rationale Δ 9 -tetrahydrocannabinol (THC), the principal intoxicant in cannabis, is a highly lipophilic substance that is readily stored in fat. Preclinical research suggests that fat-stored THC can be released into circulation under lipolytic conditions, such as stress. However, compelling evidence of this phenomenon is lacking in humans. Objectives Here, we investigated the effects of acute stress on blood (plasma) THC (and...
A Participatory Decision-making Strategy for Geoconservation Implemented in Portland, JamaicaNARA Subscribed
Geoconservation aims to protect the legacy of the Earth, and an integral component is decision-making. Decisions in geoconservation impact residents and other stakeholders; therefore, strategies to facilitate participatory decision-making are needed. Here, we present a strategy to facilitate the implementation of the Analytic Hierarchy Process (AHP) with a diverse group of stakeholders in Portland, Jamaica, without previous ex...
Linking crystal shape and dynamic undercooling: a new framework for inferring magmatic crystallization historiesNARA Subscribed
Magmas contain crystals exhibiting diverse shapes and sizes, yet the relationship between crystal shape (specifically aspect ratio) and undercooling ( $$\Delta T$$ ), the driving force for crystallization, remains poorly constrained. Crystal shape should correlate with undercooling because undercooling governs the growth regime (interface-controlled versus diffusion-controlled) and thus the resulting crystal form. Prior experi...
The East Portland Special Fishery Conservation Area (EPSFCA) is a no-take marine reserve in northeast Jamaica, established in 2016. The region is historically understudied and lacks ecological data critical for evaluating conservation outcomes. This study uses monitoring data collected with Global Coral Reef Monitoring Network methods to quantify changes in benthic, fish, and invertebrate communities from 2017 to 2024 and to e...
The disposable soma theory posits that there is a trade-off between reproduction and somatic maintenance. In support of this theory, we previously identified that pharmacological inhibition of the germline has widespread protective cell non-autonomous effects on cellular protein homeostasis in the model organism Caenorhabditis elegans . However, the cell non-autonomous effects of the germline on mitochondrial protein homeostas...
A balanced approach to the potential of octopus aquacultureNARA Subscribed