The poor efficacy of chemotherapy for glioma is mainly due to the difficulty of drug penetration through the blood–brain barrier (BBB), as well as the difficulty of drug concentration in the tumor tissue to reach the effective therapeutic level. The emerging tumor-targeted delivery technology can facilitate the precise enrichment of drugs in the tumor site. Apolipoprotein E (ApoE(159–167) 2 ) binds to low-density lipoprotein r...

During polar navigation, icebreakers frequently encounter ice ridges, which can significantly reduce navigation efficiency and even pose threats to structural safety. Therefore, studying the ramming of ice ridges by the icebreaker is of great importance. In this study, the ice ridge is decoupled into the consolidated layer and the keel for modeling. The consolidated layer is simplified as layered ice, and an innovative hybrid...