Han-Hee Cho results 116
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Integrating high-fidelity hiPSC-cardiomyocytes with AI-driven modeling for enhanced proarrhythmic risk assessmentNARA Subscribed
Cardiotoxicity remains the leading driver of drug attrition; however, its prediction remains suboptimal when conventional hERG assays and animal models are used. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer a human-relevant alternative that aligns with the CiPA initiative and ICH E14/S7B guidelines. This study validated an integrated platform that combines high-purity hiPSC-CMs with Artificial I...
Prasiola japonica is a freshwater green alga distributed in Northeast Asia. This study investigated the effects of 70% ethanol extract of P. japonica (Pj-EE) under testosterone-induced hair loss conditions using C57BL/6 mice and human dermal papilla (HDP) cells. Topical application of Pj-EE promoted hair regrowth, increased hair length, and enhanced follicular density and activity in vivo. Pj-EE treatment also partially restor...
Ground response analysis and liquefaction assessment of subsea soils at an offshore platform siteNARA Subscribed
The development of underwater infrastructure is increasingly important due to the rising demand for offshore resource utilization and marine spatial expansion. This study evaluates the seismic behavior of subsea soil at a proposed offshore platform site, focusing on liquefaction potential and cyclic softening. Site-specific geotechnical investigations, including Standard penetration tests (SPT), cone penetration tests (CPT), a...