Rapid warming across Antarctica is reshaping terrestrial ecosystems, yet the dynamics of macroscopic fungi in this region remain largely undocumented. Here, we present the first ecological and statistical assessment of Agaricales fungi on Byers Peninsula, Livingston Island (South Shetland Islands, Antarctica), based on surveys conducted in February 2023. Across 20 sites, we recorded 2,566 basidiomes representing eight morphosp...

Marinobufagin (MBG), a cardiotonic steroid from Rhinella toads, exhibits potent antitumor activity. However, their involvement in the mammalian neurotoxicity remains unclear. Therefore, this study evaluated the systemic (neuro)toxicological action of MBG to understand its central effects, particularly those associated with seizure-inducing activity. Initially, physicochemical, pharmacokinetic, and drug-likeness profiles and mo...

Cell fate determination and terminal differentiation are shaped by intrinsic molecular programs that coordinate lineage-specific gene expression. In mesenchymal stem cells (MSCs), variability in osteogenic efficiency among distinct tissue sources remains poorly understood and cannot be fully explained by differentiation conditions alone. Increasing evidence indicates that post-transcriptional regulatory mechanisms, particularl...

Spiral nematodes ( Helicotylenchus spp.) are globally distributed and are currently considered secondary pests in onion. However, a population of Helicotylenchus was recently detected causing reduced development in an onion-producing area in Rio Grande do Sul state, extreme south of Brazil. In this context, the objective of this study was to conduct a morphological, morphometric, and molecular characterization of this populati...

Purpose The management of biogenic residues in a way that extends the lifetime of carbon within the systems is a focus of the present work. Different waste management systems are assessed in terms of GHG emissions and removals, aiming to identify that with the lowest impact on climate change. Methods A life cycle comparative analysis is performed, assessing the mitigation of the impact on climate change of the current waste ma...