Helge Bode results 14
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Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Effects of Xenorhabdus and Photorhabdus bacterial metabolites on the ovipositional activity of Aedes albopictusNARA Subscribed
Viral diseases like yellow fever, dengue, and Zika have an alarming impact on public health. These diseases can be transmitted by Aedes mosquito species, such as Ae. albopictus, which is now found in many countries outside its original range. Xenorhabdus and Photorhabdus spp. are enteric bacterial symbionts of insect-preying nematodes and are known to produce an array of natural products with various activities including larvi...
Journal ClubNARA Subscribed
A rich source of new therapeutics are natural products derived from modular non-ribosomal peptide synthetases (e. g. penicillins, daptomycin). Yet, efficient bioengineering of these often gigantic megaenzymes to generate natural product analogs is a major challenge. Using synthetic zippers, we have established a co-expression strategy that not only simplifies bioengineering, but rapidly increases the biocombinatorial potential...
Climate‐specific biosynthetic gene clusters in populations of a lichen‐forming fungusNARA Subscribed
Summary Natural products can contribute to abiotic stress tolerance in plants and fungi. We hypothesize that biosynthetic gene clusters (BGCs), the genomic elements that underlie natural product biosynthesis, display structured differences along elevation gradients. We analysed biosynthetic gene variation in natural populations of the lichen‐forming fungus Umbilicaria pustulata . We collected a total of 600 individuals from th...
Cyclo(tetrahydroxybutyrate) production is sufficient to distinguish between Xenorhabdus and Photorhabdus isolates in ThailandNARA Subscribed
Summary Bacteria of the genera Photorhabdus and Xenorhabdus produce a plethora of natural products to support their similar symbiotic life cycles. For many of these compounds, the specific bioactivities are unknown. One common challenge in natural product research when trying to prioritize research efforts is the rediscovery of identical (or highly similar) compounds from different strains. Linking genome sequence to metabolit...
Metabolomics‐based chemotaxonomy of root endophytic fungi for natural products discoveryNARA Subscribed
Summary Fungi are prolific producers of natural products routinely screened for biotechnological applications, and those living endophytically within plants attract particular attention because of their purported chemical diversity. However, the harnessing of their biosynthetic potential is hampered by a large and often cryptic phylogenetic and ecological diversity, coupled with a lack of large‐scale natural products' dereplic...
Summary Xenorhabdus doucetiae , the bacterial symbiont of the entomopathogenic nematode Steinernema diaprepesi produces several different fatty acid amides. Their biosynthesis has been studied using a combination of analysis of gene deletions and promoter exchanges in X. doucetiae and heterologous expression of candidate genes in E. coli . While a decarboxylase is required for the formation of all observed phenylethylamides an...
Summary Effective iron acquisition and fine‐tuned intracellular iron storage systems are the main prerequisites for a successful host invasion by a pathogen. Bacteria have developed several different strategies to sequester this essential element from their environment, one relies on the secretion of low molecular weight compounds with high affinity for ferric iron, the so‐called siderophores. Here, we report hydroxamate sider...
Photorhabdus ‐nematode symbiosis is dependent on hfq ‐mediated regulation of secondary metabolitesNARA Subscribed
Summary Photorhabdus luminescens maintains a symbiotic relationship with the nematodes Heterorhabditis bacteriophora and together they infect and kill insect larvae. To maintain this symbiotic relationship, the bacteria must produce an array of secondary metabolites to assist in the development and replication of nematodes. The regulatory mechanisms surrounding production of these compounds are mostly unknown. The global post‐...
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