Objectives and design As an interferon-inducible protein, Viperin has broad-spectrum antiviral effects and regulation of host immune responses. We aim to investigate how Viperin regulates interferon-γ (IFN-γ) production in macrophages to control Mycobacterium tuberculosis (Mtb) infection. Methods We use Viperin deficient bone-marrow-derived macrophage (BMDM) to investigate the effects and machines of Viperin on Mtb infection....

Purpose This study aims to evaluate the biomechanical characteristics of percutaneous antegrade and retrograde screws in treating superior pubic rami fractures in zone II, employing finite element analysis. It provides a theoretical basis for the treatment of the superior rami of pubis zone II fracture. Methods The software of Mimics and 3-Matic were utilized for reconstructing a fracture model of the superior pubic rami in zo...

Traumatic brain injury (TBI) leads to disturbed brain discharge rhythm, elevated excitability, anxiety-like behaviors, and decreased learning and memory capabilities. Cognitive dysfunctions severely affect the quality of life and prognosis of TBI patients, requiring effective rehabilitation treatment. Evidence indicates that moderate exercise after brain injury decreases TBI-induced cognitive decline. However, the underlying m...